Expression of heparanase in basal cell carcinoma and squamous cell carcinoma

• Published in: Anais brasileiros de dermatología Vol. 91; no. 5; pp. 595 - 600
• Main Authors: Pinhal, Maria Aparecida Silva, Almeida, Maria Carolina Leal, Costa, Alessandra Scorse, Theodoro, Thérèse Rachell, Serrano, Rodrigo Lorenzetti, Machado Filho, Carlos D'Apparecida Santos
• Format: Journal Article
• Language: English
• Published: Spain Sociedade Brasileira de Dermatologia 01.09.2016
• Subjects: Carcinoma, basal cell; Carcinoma, Basal Cell - enzymology; Carcinoma, squamous cell; Carcinoma, Squamous Cell - enzymology; DERMATOLOGY; Eyelids - enzymology; Glucuronidase - genetics; Glucuronidase - metabolism; Glycosaminoglycans; Glycosaminoglycans - analysis; Glycosaminoglycans - metabolism; Humans; Hyaluronic acid; Hyaluronic Acid - analysis; Hyaluronic Acid - metabolism; Investigation; Keratinocytes - metabolism; Neoplasms; Polymerase chain reaction; Real-Time Polymerase Chain Reaction - methods; RNA, Messenger - metabolism; Skin neoplasms; Skin Neoplasms - enzymology; Polymerase chain reaction; Carcinoma, squamous cell; Glycosaminoglycans; Skin neoplasms; Carcinoma, basal cell; Hyaluronic acid; Neoplasms

Heparanase is an enzyme that cleaves heparan sulfate chains. Oligosaccharides generated by heparanase induce tumor progression. Basal cell carcinoma and squamous cell carcinoma comprise types of nonmelanoma skin cancer. Evaluate the glycosaminoglycans profile and expression of heparanase in two huma...