Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1 - Cha, Jong-Ho; Yang, Wen-Hao; Xia, Weiya; Wei, Yongkun; Chan, Li-Chuan; Lim, Seung-Oe; Li, Chia-Wei; Kim, Taewan; Chang, Shih-Shin; Lee, Heng-Huan; Hsu, Jennifer L.; Wang, Hung-Ling; et al. (Molecular cell, 2018)
Keywords: AMP-activated protein kinase; AMP-Activated Protein Kinases - genetics; AMP-Activated Protein Kinases - immunology; Animals; antineoplastic activity; Antineoplastic Agents - pharmacology; B7-H1 Antigen - genetics; B7-H1 Antigen - immunology; breast neoplasms; cancer immunotherapy; Cell Line, Tumor; CTLA-4 Antigen - genetics; CTLA-4 Antigen - immunology; Endoplasmic Reticulum - drug effects; Endoplasmic Reticulum - genetics; Endoplasmic Reticulum - metabolism; Endoplasmic Reticulum-Associated Degradation; Epithelial Cells - cytology; Epithelial Cells - drug effects; Epithelial Cells - immunology; ER accumulation; ERAD; Female; Gene Expression Regulation, Neoplastic; Glycosylation; Humans; Hypoglycemic Agents - pharmacology; immune checkpoint blockade; immunity; immunotherapy; Mammary Glands, Human - cytology; Mammary Glands, Human - drug effects; Mammary Glands, Human - immunology; Melanoma, Experimental - drug therapy; Melanoma, Experimental - genetics; Melanoma, Experimental - immunology; Melanoma, Experimental - pathology; metformin; Metformin - pharmacology; Mice; Mice, Inbred NOD; monitoring; neoplasm cells; patients; PD-L1; Phosphorylation; protein degradation; Serine - metabolism; T-Lymphocytes, Cytotoxic - cytology; T-Lymphocytes, Cytotoxic - drug effects; T-Lymphocytes, Cytotoxic - immunology; tissues; ERAD; ER accumulation; cancer immunotherapy; PD-L1; metformin; glycosylation; immune checkpoint blockade