Treprostinil reduces mitochondrial injury during rat renal ischemia-reperfusion injury - Ding, Meiwen; Tolbert, Evelyn; Birkenbach, Mark; Gohh, Reginald; Akhlaghi, Fatemeh; Ghonem, Nisanne S. (Biomedicine & pharmacotherapy, 2021)
Keywords: Acute kidney injury; Acute Kidney Injury - drug therapy; Acute Kidney Injury - metabolism; Acute Kidney Injury - pathology; Animals; Antihypertensive Agents - pharmacology; Antihypertensive Agents - therapeutic use; Apoptosis; Apoptosis - drug effects; Apoptosis - physiology; Epoprostenol - analogs & derivatives; Epoprostenol - pharmacology; Epoprostenol - therapeutic use; Kidney - blood supply; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; Male; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondria - pathology; Oxidative Stress - drug effects; Oxidative Stress - physiology; Prostacyclin; Rats; Rats, Sprague-Dawley; Reperfusion Injury - drug therapy; Reperfusion Injury - metabolism; Reperfusion Injury - pathology; IRI; PAS; mtDNA; Cox IV; SWATH-MS; Prostacyclin; Mff; Drp1; Gclc; Mitochondria; TUNEL; Opa1; Mfn1; Mfn2; GSH; AKI; Nqo1; SCr; PGI2; Acute kidney injury; SOD; pErk1/2; CAT; Sirt3; Pgc-1α; Apoptosis