Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironment

• Published in: DNA repair Vol. 32; pp. 180 - 189
• Main Authors: Scanlon, Susan E., Glazer, Peter M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2015
• Subjects: Ataxia Telangiectasia Mutated Proteins - genetics; Ataxia Telangiectasia Mutated Proteins - metabolism; Cell Hypoxia; DNA Breaks, Double-Stranded; DNA damage response; DNA Mismatch Repair; DNA repair; DNA, Neoplasm - chemistry; DNA, Neoplasm - metabolism; Gene Expression Regulation, Neoplastic; Gene regulation; Gene silencing; Genetic instability; Genomic Instability; Humans; Hypoxia; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Post-translational modifications; Protein Processing, Post-Translational; Replication stress; Signal Transduction; Tumor microenvironment; Tumor Microenvironment - genetics; H3K9me2; DNA damage response; H3K9me3; Gene regulation; PTM; HR; PARP; Genetic instability; DNA repair; DSB; TLS; TSA; HIF; Tumor microenvironment; JHDM; H3K4me3; H3K4me2; BER; Gene silencing; MMR; Post-translational modifications; Replication stress; Hypoxia; ATM; HRE; NER; NHEJ; ATR; HDAC

Hypoxia, as a pervasive feature in the microenvironment of solid tumors, plays a significant role in cancer progression, metastasis, and ultimately clinical outcome. One key cellular consequence of hypoxic stress is the regulation of DNA repair pathways, which contributes to the genomic instability...