IoT PCR for pandemic disease detection and its spread monitoring
•We show a highly integrated internet of things (IoT) system based on polymerase chain reaction for disease detection and monitoring its spreading.•The detection results were automatically uploaded via a Bluetooth interface to user's smartphone.•Together with global positioning system coordinat...
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| Published in | Sensors and actuators. B, Chemical Vol. 303; p. 127098 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Elsevier B.V
15.01.2020
Elsevier Science Ltd |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0925-4005 1873-3077 0925-4005 |
| DOI | 10.1016/j.snb.2019.127098 |
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| Abstract | •We show a highly integrated internet of things (IoT) system based on polymerase chain reaction for disease detection and monitoring its spreading.•The detection results were automatically uploaded via a Bluetooth interface to user's smartphone.•Together with global positioning system coordinates of the test spot at further sent via global network.•The map of the infectious disease outbreak was instantly produced.•This device can be used for other diseases and become a basic block of the IoT helping to tackle infectious disease outbreak.
During infectious disease outbreaks, the centers for disease control need to monitor particular areas. Considerable effort has been invested in the development of portable, user-friendly, and cost-effective systems for point-of-care (POC) diagnostics, which could also create an Internet of Things (IoT) for healthcare via a global network. However, at present IoT based on a functional POC instrument is not available. Here we show a fast, user-friendly, and affordable IoT system based on a miniaturized polymerase chain reaction device. We demonstrated the system’s capability by amplification of complementary deoxyribonucleic acid (cDNA) of the dengue fever virus. The resulting data were then automatically uploaded via a Bluetooth interface to an Android-based smartphone and then wirelessly sent to a global network, instantly making the test results available anywhere in the world. The IoT system presented here could become an essential tool for healthcare centers to tackle infectious disease outbreaks identified either by DNA or ribonucleic acid. |
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| AbstractList | During infectious disease outbreaks, the centers for disease control need to monitor particular areas. Considerable effort has been invested in the development of portable, user-friendly, and cost-effective systems for point-of-care (POC) diagnostics, which could also create an Internet of Things (IoT) for healthcare via a global network. However, at present IoT based on a functional POC instrument is not available. Here we show a fast, user-friendly, and affordable IoT system based on a miniaturized polymerase chain reaction device. We demonstrated the system's capability by amplification of complementary deoxyribonucleic acid (cDNA) of the dengue fever virus. The resulting data were then automatically uploaded via a Bluetooth interface to an Android-based smartphone and then wirelessly sent to a global network, instantly making the test results available anywhere in the world. The IoT system presented here could become an essential tool for healthcare centers to tackle infectious disease outbreaks identified either by DNA or ribonucleic acid.During infectious disease outbreaks, the centers for disease control need to monitor particular areas. Considerable effort has been invested in the development of portable, user-friendly, and cost-effective systems for point-of-care (POC) diagnostics, which could also create an Internet of Things (IoT) for healthcare via a global network. However, at present IoT based on a functional POC instrument is not available. Here we show a fast, user-friendly, and affordable IoT system based on a miniaturized polymerase chain reaction device. We demonstrated the system's capability by amplification of complementary deoxyribonucleic acid (cDNA) of the dengue fever virus. The resulting data were then automatically uploaded via a Bluetooth interface to an Android-based smartphone and then wirelessly sent to a global network, instantly making the test results available anywhere in the world. The IoT system presented here could become an essential tool for healthcare centers to tackle infectious disease outbreaks identified either by DNA or ribonucleic acid. • We show a highly integrated internet of things (IoT) system based on polymerase chain reaction for disease detection and monitoring its spreading. • The detection results were automatically uploaded via a Bluetooth interface to user's smartphone. • Together with global positioning system coordinates of the test spot at further sent via global network. • The map of the infectious disease outbreak was instantly produced. • This device can be used for other diseases and become a basic block of the IoT helping to tackle infectious disease outbreak. During infectious disease outbreaks, the centers for disease control need to monitor particular areas. Considerable effort has been invested in the development of portable, user-friendly, and cost-effective systems for point-of-care (POC) diagnostics, which could also create an Internet of Things (IoT) for healthcare via a global network. However, at present IoT based on a functional POC instrument is not available. Here we show a fast, user-friendly, and affordable IoT system based on a miniaturized polymerase chain reaction device. We demonstrated the system’s capability by amplification of complementary deoxyribonucleic acid (cDNA) of the dengue fever virus. The resulting data were then automatically uploaded via a Bluetooth interface to an Android-based smartphone and then wirelessly sent to a global network, instantly making the test results available anywhere in the world. The IoT system presented here could become an essential tool for healthcare centers to tackle infectious disease outbreaks identified either by DNA or ribonucleic acid. During infectious disease outbreaks, the centers for disease control need to monitor particular areas. Considerable effort has been invested in the development of portable, user-friendly, and cost-effective systems for point-of-care (POC) diagnostics, which could also create an Internet of Things (IoT) for healthcare via a global network. However, at present IoT based on a functional POC instrument is not available. Here we show a fast, user-friendly, and affordable IoT system based on a miniaturized polymerase chain reaction device. We demonstrated the system's capability by amplification of complementary deoxyribonucleic acid (cDNA) of the dengue fever virus. The resulting data were then automatically uploaded via a Bluetooth interface to an Android-based smartphone and then wirelessly sent to a global network, instantly making the test results available anywhere in the world. The IoT system presented here could become an essential tool for healthcare centers to tackle infectious disease outbreaks identified either by DNA or ribonucleic acid. •We show a highly integrated internet of things (IoT) system based on polymerase chain reaction for disease detection and monitoring its spreading.•The detection results were automatically uploaded via a Bluetooth interface to user's smartphone.•Together with global positioning system coordinates of the test spot at further sent via global network.•The map of the infectious disease outbreak was instantly produced.•This device can be used for other diseases and become a basic block of the IoT helping to tackle infectious disease outbreak. During infectious disease outbreaks, the centers for disease control need to monitor particular areas. Considerable effort has been invested in the development of portable, user-friendly, and cost-effective systems for point-of-care (POC) diagnostics, which could also create an Internet of Things (IoT) for healthcare via a global network. However, at present IoT based on a functional POC instrument is not available. Here we show a fast, user-friendly, and affordable IoT system based on a miniaturized polymerase chain reaction device. We demonstrated the system’s capability by amplification of complementary deoxyribonucleic acid (cDNA) of the dengue fever virus. The resulting data were then automatically uploaded via a Bluetooth interface to an Android-based smartphone and then wirelessly sent to a global network, instantly making the test results available anywhere in the world. The IoT system presented here could become an essential tool for healthcare centers to tackle infectious disease outbreaks identified either by DNA or ribonucleic acid. |
| ArticleNumber | 127098 |
| Author | Liu, Xiaocheng Podesva, Pavel Li, Yu Neuzil, Pavel Chang, Honglong Iliescu, Ciprian Teply, Tomas Zhang, Haoqing Zhu, Hanliang Qian, Airong Xu, Ying Niculescu, Andreea Lei, Yingfeng |
| Author_xml | – sequence: 1 givenname: Hanliang surname: Zhu fullname: Zhu, Hanliang organization: Ministry of Education Key Laboratory of Micro/Nano Systems for Aerospace, School of Mechanical Engineering, Northwestern Polytechnical University, Xi’an 710072, PR China – sequence: 2 givenname: Pavel surname: Podesva fullname: Podesva, Pavel organization: Ministry of Education Key Laboratory of Micro/Nano Systems for Aerospace, School of Mechanical Engineering, Northwestern Polytechnical University, Xi’an 710072, PR China – sequence: 3 givenname: Xiaocheng surname: Liu fullname: Liu, Xiaocheng organization: Ministry of Education Key Laboratory of Micro/Nano Systems for Aerospace, School of Mechanical Engineering, Northwestern Polytechnical University, Xi’an 710072, PR China – sequence: 4 givenname: Haoqing surname: Zhang fullname: Zhang, Haoqing organization: Ministry of Education Key Laboratory of Micro/Nano Systems for Aerospace, School of Mechanical Engineering, Northwestern Polytechnical University, Xi’an 710072, PR China – sequence: 5 givenname: Tomas surname: Teply fullname: Teply, Tomas organization: Czech Technical University in Prague, Technická 2, 166 27 Praha 6, Czech Republic – sequence: 6 givenname: Ying surname: Xu fullname: Xu, Ying organization: Ministry of Education Key Laboratory of Micro/Nano Systems for Aerospace, School of Mechanical Engineering, Northwestern Polytechnical University, Xi’an 710072, PR China – sequence: 7 givenname: Honglong surname: Chang fullname: Chang, Honglong organization: Ministry of Education Key Laboratory of Micro/Nano Systems for Aerospace, School of Mechanical Engineering, Northwestern Polytechnical University, Xi’an 710072, PR China – sequence: 8 givenname: Airong surname: Qian fullname: Qian, Airong organization: School of Life Science, Northwesstern Polytechnical University, Xi’an 710072, PR China – sequence: 9 givenname: Yingfeng surname: Lei fullname: Lei, Yingfeng organization: Air Force Military Medical University, 169 Changle West Road, Xi'an, Shaanxi, 710032, PR China – sequence: 10 givenname: Yu surname: Li fullname: Li, Yu organization: School of Life Science, Northwesstern Polytechnical University, Xi’an 710072, PR China – sequence: 11 givenname: Andreea surname: Niculescu fullname: Niculescu, Andreea organization: Institute for Infocomm Research, A⁎STAR, 1 Fusionopolis Way, #21-01 Connexis (South Tower), 138632, Singapore – sequence: 12 givenname: Ciprian surname: Iliescu fullname: Iliescu, Ciprian email: ipi_sil@yahoo.com organization: National Institute for Research and Development in Microtechnologies, IMT-Bucharest, Bucharest 077190, Romania – sequence: 13 givenname: Pavel surname: Neuzil fullname: Neuzil, Pavel email: pavel.neuzil@nwpu.edu.cn organization: Ministry of Education Key Laboratory of Micro/Nano Systems for Aerospace, School of Mechanical Engineering, Northwestern Polytechnical University, Xi’an 710072, PR China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32288256$$D View this record in MEDLINE/PubMed |
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| Keywords | Infectious diseases Dengue fever PCR IoT |
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| Snippet | •We show a highly integrated internet of things (IoT) system based on polymerase chain reaction for disease detection and monitoring its spreading.•The... During infectious disease outbreaks, the centers for disease control need to monitor particular areas. Considerable effort has been invested in the development... • We show a highly integrated internet of things (IoT) system based on polymerase chain reaction for disease detection and monitoring its spreading. • The... |
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| SubjectTerms | Bluetooth Dengue fever Deoxyribonucleic acid Disease control DNA Epidemics Health care Infectious diseases Internet of Things IoT Outbreaks PCR Polymerase chain reaction Smartphones System effectiveness Viral diseases Viruses |
| Title | IoT PCR for pandemic disease detection and its spread monitoring |
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