Prolactin gene polymorphism (−1149 G/T) is associated with hyperprolactinemia in patients with schizophrenia treated with antipsychotics

• Published in: Schizophrenia research Vol. 182; pp. 110 - 114
• Main Authors: Ivanova, Svetlana A., Osmanova, Diana Z., Boiko, Anastasia S., Pozhidaev, Ivan V., Freidin, Maxim B., Fedorenko, Olga Yu, Semke, Arkadiy V., Bokhan, Nikolay A., Kornetova, Elena G., Rakhmazova, Lubov D., Wilffert, Bob, Loonen, Anton J.M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2017
• Subjects: 1149 G/T polymorphism; Adolescent; Adult; Aged; Antipsychotic Agents - adverse effects; Cytokines; Female; Gene Frequency; Genetic Association Studies; Genotype; Humans; Hyperprolactinemia; Hyperprolactinemia - chemically induced; Hyperprolactinemia - genetics; Male; Middle Aged; Polymorphism, Single Nucleotide - genetics; PRL; Prolactin; Prolactin - blood; Prolactin - genetics; Psychiatry; Schizophrenia; Schizophrenia - blood; Schizophrenia - drug therapy; Schizophrenia - genetics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Statistics, Nonparametric; Young Adult; Schizophrenia; 1149 G/T polymorphism; PRL; Cytokines; Prolactin; Hyperprolactinemia

Antipsychotic drugs can cause hyperprolactinemia. However, hyperprolactinemia was also observed in treatment-naive patients with a first schizophrenic episode. This phenomenon might be related to the role of prolactin as a cytokine in autoimmune diseases. Extrapituitary prolactin production is regul...