FTH1- and SAT1-Induced Astrocytic Ferroptosis Is Involved in Alzheimer’s Disease: Evidence from Single-Cell Transcriptomic Analysis

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 15; no. 10; p. 1177
• Main Authors: Dang, Yini, He, Qing, Yang, Siyu, Sun, Huaiqing, Liu, Yin, Li, Wanting, Tang, Yi, Zheng, Yu, Wu, Ting
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 22.09.2022; MDPI
• Subjects: Alzheimer's disease; Analysis; Astrocytes; Cell death; Cognitive ability; Communication; Development and progression; ferroptosis; Gene expression; Genetic aspects; Genomics; Health aspects; Ligands; Neurons; Phosphorylation; Physiological aspects; Proteins; Risk factors; RNA sequencing; single-cell RNA sequencing; China
• ISSN: 1424-8247; 1424-8247
• DOI: 10.3390/ph15101177

Objectives: Despite significant advances in neuroscience, the mechanisms of AD are not fully understood. Single-cell RNA sequencing (scRNA-seq) techniques provide potential solutions to analyze cellular composition of complex brain tissue and explore cellular and molecular biological mechanisms of A...