Genome-wide allelic imbalance analysis of pediatric gliomas by single nucleotide polymorphic allele array

• Published in: Cancer research (Chicago, Ill.) Vol. 66; no. 23; pp. 11172 - 11178
• Main Authors: WONG, Kwong-Kwok, TSANG, Yvonne T. M, BHATTACHARJEE, Meenakshi, CHINTAGUMPALA, Murali, LAU, Ching C, CHANG, Yi-Mieng, SU, Jack, DI FRANCESCO, Angela M, MECO, Daniela, RICCARDI, Riccardo, PERLAKY, Laszlo, DAUSER, Robert C, ADESINA, Adekunle
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.12.2006
• Subjects: Alleles; Antineoplastic agents; Base Sequence; Biological and medical sciences; Cell Cycle - genetics; Child; DNA Mutational Analysis; Gene Amplification; Gene Expression Regulation, Neoplastic - genetics; Genome, Human - genetics; Genotype; Glioblastoma - genetics; Glioblastoma - pathology; Glioma - genetics; Glioma - pathology; Humans; Loss of Heterozygosity; Medical sciences; Neurology; Pharmacology. Drug treatments; Polymorphism, Single Nucleotide - genetics; Receptor, Epidermal Growth Factor - genetics; Receptor, Platelet-Derived Growth Factor alpha - genetics; Reverse Transcriptase Polymerase Chain Reaction; Tumors; Tumors of the nervous system. Phacomatoses; Human; Pediatrics; Nervous system diseases; Allelic imbalance; DNA chip; Infant; Allele; Glioma; Central nervous system disease; Loss of heterozygosity; Nucleotide; Tumor; Genetics; Genome; Child; Polymorphism

Using single nucleotide polymorphic (SNP) allele arrays, we analyzed 28 pediatric gliomas consisting of 14 high-grade gliomas and 14 low-grade gliomas. Most of the low-grade gliomas had no detectable loss of heterozygosity (LOH) in any of the 11,562 SNP loci; exceptions were two gangliogliomas (3q a...