Determination of [11C]PBR28 Binding Potential in vivo: A First Human TSPO Blocking Study

• Published in: Journal of cerebral blood flow and metabolism Vol. 34; no. 6; pp. 989 - 994
• Main Authors: Owen, David R, Guo, Qi, Kalk, Nicola J, Colasanti, Alessandro, Kalogiannopoulou, Dimitra, Dimber, Rahul, Lewis, Yvonne L, Libri, Vincenzo, Barletta, Julien, Ramada-Magalhaes, Joaquim, Kamalakaran, Aruloly, Nutt, David J, Passchier, Jan, Matthews, Paul M, Gunn, Roger N, Rabiner, Eugenii A
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.06.2014; Sage Publications Ltd; Nature Publishing Group
• Subjects: Acetamides - administration & dosage; Adult; Brain - diagnostic imaging; Brain - metabolism; Carbon Isotopes - administration & dosage; Dose-Response Relationship, Drug; Drug Delivery Systems; Female; Humans; Male; Original; Positron-Emission Tomography; Purines - administration & dosage; Pyridines - administration & dosage; Radiography; Receptors, GABA - metabolism; [11C]PBR28; TSPO; specific binding; rs6971 polymorphism; emapunil; XBD173

Positron emission tomography (PET) targeting the 18 kDa translocator protein (TSPO) is used to quantify neuroinflammation. Translocator protein is expressed throughout the brain, and therefore a classical reference region approach cannot be used to estimate binding potential (BPND). Here, we used bl...