Large-Scale Investigation of Base Excision Repair Genetic Polymorphisms and Lung Cancer Risk in a Multicenter Study

• Published in: JNCI : Journal of the National Cancer Institute Vol. 97; no. 8; pp. 567 - 576
• Main Authors: Hung, Rayjean J., Brennan, Paul, Canzian, Federico, Szeszenia-Dabrowska, Neonila, Zaridze, David, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Mates, Dana, Foretova, Lenka, Janout, Vladimir, Bencko, Vladimir, Chabrier, Amelie, Borel, Stephane, Hall, Janet, Boffetta, Paolo
• Format: Journal Article
• Language: English
• Published: Cary, NC Oxford University Press 20.04.2005; Oxford Publishing Limited (England)
• Subjects: Adenocarcinoma - epidemiology; Adenocarcinoma - etiology; Adenocarcinoma - genetics; Adult; Aged; Arginine; Case-Control Studies; Confounding Factors (Epidemiology); Cysteine; DNA Repair; Europe, Eastern - epidemiology; Female; Genotype; Humans; Logistic Models; Lung cancer; Lung Neoplasms - epidemiology; Lung Neoplasms - etiology; Lung Neoplasms - genetics; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Polymorphism, Genetic; Research Design; Risk Assessment; Risk Factors; Selection Bias; Serine; Smoking - adverse effects; Tryptophan; Europe, Eastern

Background: Base excision repair (BER) is a highly conserved essential mechanism for maintaining genome integrity. We examined associations among four well-characterized polymorphisms of BER genes (OGG1 Ser326Cys, XRCC1 Arg194Trp, XRCC1 Arg280His, and XRCC1 Arg399Gln) and lung cancer risk. Methods:...