Diurnal Rhythmicity of Autophagy Is Impaired in the Diabetic Retina

• Published in: Cells (Basel, Switzerland) Vol. 9; no. 4; p. 905
• Main Authors: Qi, Xiaoping, Mitter, Sayak K., Yan, Yuanqing, Busik, Julia V, Grant, Maria B, Boulton, Michael E
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 07.04.2020; MDPI AG
• Subjects: Animals; autophagy; Autophagy - genetics; Chronobiology Disorders - complications; Circadian Rhythm - genetics; diabetes; Diabetes Complications - genetics; diabetic retinopathy; Diabetic Retinopathy - genetics; diurnal rhythm; Female; Humans; Male; Mice; Rats; Rats, Inbred BB; retina; Retina - pathology; diurnal rhythm; autophagy; diabetic retinopathy; retina; diabetes

Retinal homeostasis is under both diurnal and circadian regulation. We sought to investigate the diurnal expression of autophagy proteins in normal rodent retina and to determine if this is impaired in diabetic retinopathy. C57BL/6J mice and Bio-Breeding Zucker (BBZ) rats were maintained under a 12h...