Microneedle-assisted dual delivery of PUMA gene and celastrol for synergistic therapy of rheumatoid arthritis through restoring synovial homeostasis

• Published in: Bioactive materials Vol. 36; pp. 83 - 95
• Main Authors: Hua, Peng, Liang, Ruifeng, Yang, Suleixin, Tu, Yanbei, Chen, Meiwan
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.06.2024; KeAi Publishing Communications Ltd; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: Anti-inflammation; Apoptosis; Arthritis; Cartilage; Celastrol; Cell activation; Cell death; Disease; Drug delivery; Drugs; Effectiveness; Fibroblast-like synoviocyte apoptosis; Fibroblasts; Gene therapy; Homeostasis; Human serum albumin; Hyaluronic acid; Hyperplasia; Inflammation; Macrophages; Medical research; Microenvironments; Natural products; Needles; NF-κB protein; Polyethyleneimine; Proteins; PUMA; Rheumatoid arthritis; Serum albumin; Signal transduction; Skin; Synoviocytes; Transfection; Tumor necrosis factor-TNF; Vectors (Biology); United States > US; China; Fibroblast-like synoviocyte apoptosis; PUMA; Rheumatoid arthritis; Celastrol; Anti-inflammation

Abnormal proliferation of aggressive fibroblast-like synoviocytes (FLS) and perpetuate synovial inflammation can inevitably accelerate the progression of rheumatoid arthritis (RA). Herein, a strategy of simultaneously promoting FLS apoptosis and inhibiting inflammation as mediated by macrophages is...