Effect of Disrupted SOX18 Transcription Factor Function on Tumor Growth, Vascularization, and Endothelial Development

• Published in: JNCI : Journal of the National Cancer Institute Vol. 98; no. 15; pp. 1060 - 1067
• Main Authors: Young, Neville, Hahn, Christopher N., Poh, Alisa, Dong, Carolyn, Wilhelm, Dagmar, Olsson, Jane, Muscat, George E. O., Parsons, Peter, Gamble, Jennifer R., Koopman, Peter
• Format: Journal Article
• Language: English
• Published: Cary, NC Oxford University Press 02.08.2006; Oxford Publishing Limited (England)
• Subjects: Adenoviridae; Animal tumors. Experimental tumors; Animals; Antigens - analysis; Biological and medical sciences; Blotting, Northern; Breast cancer; Breast Neoplasms - blood supply; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Cell adhesion & migration; Cell Movement; Cell Proliferation; Colorectal Neoplasms - metabolism; Embryo, Mammalian - metabolism; Endothelium, Vascular - growth & development; Endothelium, Vascular - metabolism; Experimental tumors, general aspects; Gene Expression Regulation, Neoplastic; Genetic markers; High Mobility Group Proteins - genetics; High Mobility Group Proteins - metabolism; Humans; Immunohistochemistry; In Situ Hybridization; Medical sciences; Melanoma - blood supply; Melanoma - genetics; Melanoma - metabolism; Mice; Mice, Inbred C57BL; Mutation; Neovascularization, Pathologic - metabolism; Platelet Endothelial Cell Adhesion Molecule-1 - analysis; Proteoglycans - analysis; Rodents; Skin cancer; SOXF Transcription Factors; Transcription Factors - genetics; Transcription Factors - metabolism; Transgenic animals; Transplantation, Homologous; Tumors; Umbilical Veins; Up-Regulation; Human; Endothelial cell; Rodentia; Malignant tumor; Cell differentiation; Carcinogenesis; Vascularization; Angiogenesis; Signal transduction; Vertebrata; Mammalia; Cancerology; Mouse; Tumor growth; Animal; Transcription factor
• ISSN: 0027-8874; 1460-2105; 1460-2105
• DOI: 10.1093/jnci/djj299

Background: The growth of solid tumors depends on establishing blood supply; thus, inhibiting tumor angiogenesis has been a long-term goal in cancer therapy. The SOX18 transcription factor is a key regulator of murine and human blood vessel formation. Methods: We established allograft melanoma tumor...