Role of A-Kinase Anchoring Protein Phosphorylation in Alcohol-Induced Liver Injury and Hepatic Stellate Cell Activation

• Published in: The American journal of pathology Vol. 188; no. 3; pp. 640 - 655
• Main Authors: Ramani, Komal, Tomasi, Maria Lauda, Berlind, Joshua, Mavila, Nirmala, Sun, Zhaoli
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2018; American Society for Investigative Pathology

Alcoholic liver injury is associated with hepatic stellate cell (HSC) activation. A-kinase anchoring protein 12 (AKAP12) scaffolds protein kinase C and cyclin-D1, which is regulated by its phosphorylation, and spatiotemporally controls cell proliferation, invasiveness, and chemotaxis. HSC activation...