Chondroitin Sulfate Proteoglycan 4 Provides New Treatment Approach to Preventing Peritoneal Dissemination in Ovarian Cancer

• Published in: International journal of molecular sciences Vol. 25; no. 3; p. 1626
• Main Authors: Uno, Kaname, Koya, Yoshihiro, Yoshihara, Masato, Iyoshi, Shohei, Kitami, Kazuhisa, Sugiyama, Mai, Miyamoto, Emiri, Mogi, Kazumasa, Fujimoto, Hiroki, Yamakita, Yoshihiko, Wang, Xinhui, Nawa, Akihiro, Kajiyama, Hiroaki
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 2024
• Subjects: Ascites; Basic Medicine; cancer spheroids; Cell and Molecular Biology; Cell- och molekylärbiologi; Cells; cell–cell interaction; Chondroitin; Chondroitin sulfate; Ferrone, Soldano; Health aspects; Medical and Health Sciences; Medical prognosis; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; Metastasis; Ovarian cancer; peritoneal metastasis; Prevention; Protein expression; Proteins; Spheres; Spheroids; Sulfates; Tumors; Wound healing; Japan; cancer spheroids; cell–cell interaction; ovarian cancer; chondroitin sulfate; peritoneal metastasis

Most epithelial ovarian cancer (EOC) patients are diagnosed with peritoneal dissemination. Cellular interactions are an important aspect of EOC cells when they detach from the primary site of the ovary. However, the mechanism remains underexplored. Our study aimed to reveal the role of chondroitin s...