An active shrinkage and antioxidative hydrogel with biomimetic mechanics functions modulates inflammation and fibrosis to promote skin regeneration

• Published in: Bioactive materials Vol. 45; pp. 322 - 344
• Main Authors: Zhang, Tao, Zhong, Xin-Cao, Feng, Zi-Xuan, Lin, Xiao-Ying, Chen, Chun-Ye, Wang, Xiao-Wei, Guo, Kai, Wang, Yi, Chen, Jun, Du, Yong-Zhong, Zhuang, Ze-Ming, Wang, Yong, Tan, Wei-Qiang
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.03.2025; KeAi Publishing Communications Ltd; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: ACEI microspheres; Active shrinkage and antioxidative hydrogel; Anti-inflammation and anti-fibrosis; Biocompatibility; Biomechanics; Biomimetic mechanics; Biomimetics; Body temperature; Collagen; Contractility; Drug delivery systems; Drugs; Fibroblasts; Fibrosis; Genotype & phenotype; Hydrogels; Inflammation; Macrophages; Mechanical properties; Mechanics; Microenvironments; Modulus of elasticity; Oxidative stress; Phenotypes; Regeneration; Scars; Skin; Skin regeneration; Storage modulus; Wound healing; Biomimetic mechanics; Skin regeneration; Anti-inflammation and anti-fibrosis; ACEI microspheres; Active shrinkage and antioxidative hydrogel

Achieving scar-free skin regeneration in clinical settings presents significant challenges. Key issues such as the imbalance in macrophage phenotype transition, delayed re-epithelialization, and excessive proliferation and differentiation of fibroblasts hinder wound healing and lead to fibrotic repa...