Diphencyprone as a therapeutic option in cutaneous metastasis of melanoma. A single-institution experience

Diphencyprone has been reported as a local immunotherapy for cutaneous melanoma metastases. We aim to report cases of melanoma patients treated with diphencyprone in a single Brazilian institution and highlight their outcomes. Since 2012, we have treated 16 melanoma patients with cutaneous metastase...

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Published inAnais brasileiros de dermatología Vol. 93; no. 2; pp. 299 - 301
Main Authors Gibbons, Ivana Lameiras, Sonagli, Marina, Bertolli, Eduardo, Macedo, Mariana Petaccia de, Pinto, Clovis Antonio Lopes, Duprat Neto, João Pedreira
Format Journal Article
LanguageEnglish
Portuguese
Published Spain Sociedade Brasileira de Dermatologia 01.03.2018
Subjects
Administration, Cutaneous
Adult
Aged
Aged, 80 and over
Antineoplastic Agents - therapeutic use
Biopsy
Brazil
Communication
Cyclopropanes - therapeutic use
DERMATOLOGY
Female
Humans
Male
Melanoma
Melanoma - drug therapy
Melanoma - pathology
Melanoma - secondary
Middle Aged
Neoplasm metastasis
Skin Neoplasms - drug therapy
Skin Neoplasms - pathology
Skin Neoplasms - secondary
Therapeutics
Treatment Outcome
Young Adult
Neoplasm metastasis
Melanoma
Therapeutics
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Abstract Diphencyprone has been reported as a local immunotherapy for cutaneous melanoma metastases. We aim to report cases of melanoma patients treated with diphencyprone in a single Brazilian institution and highlight their outcomes. Since 2012, we have treated 16 melanoma patients with cutaneous metastases with topical diphencyprone. To date, we have had 37.5% of complete response, 25% of partial responses, and 31.25% patients without any response. Treatment was well tolerated and local toxicity was easily controlled. We believe topical diphencyprone is a feasible treatment that can be another option for treating melanoma patients, especially in cases of in-transit or extensive disease.
AbstractList Diphencyprone has been reported as a local immunotherapy for cutaneous melanoma metastases. We aim to report cases of melanoma patients treated with diphencyprone in a single Brazilian institution and highlight their outcomes. Since 2012, we have treated 16 melanoma patients with cutaneous metastases with topical diphencyprone. To date, we have had 37.5% of complete response, 25% of partial responses, and 31.25% patients without any response. Treatment was well tolerated and local toxicity was easily controlled. We believe topical diphencyprone is a feasible treatment that can be another option for treating melanoma patients, especially in cases of in-transit or extensive disease.
Diphencyprone has been reported as a local immunotherapy for cutaneous melanoma metastases. We aim to report cases of melanoma patients treated with diphencyprone in a single Brazilian institution and highlight their outcomes. Since 2012, we have treated 16 melanoma patients with cutaneous metastases with topical diphencyprone. To date, we have had 37.5% of complete response, 25% of partial responses, and 31.25% patients without any response. Treatment was well tolerated and local toxicity was easily controlled. We believe topical diphencyprone is a feasible treatment that can be another option for treating melanoma patients, especially in cases of in-transit or extensive disease.
Author Macedo, Mariana Petaccia de
Duprat Neto, João Pedreira
Gibbons, Ivana Lameiras
Pinto, Clovis Antonio Lopes
Bertolli, Eduardo
Sonagli, Marina
AuthorAffiliation 2 Oncology Residency Training Program - AC Camargo Cancer Center - São Paulo (SP), Brazil
1 Skin Cancer Center - AC Camargo Cancer Center - São Paulo (SP), Brazil
3 Department of Pathology - AC Camargo Cancer Center - São Paulo (SP), Brazil
AuthorAffiliation_xml – name: 2 Oncology Residency Training Program - AC Camargo Cancer Center - São Paulo (SP), Brazil
– name: 3 Department of Pathology - AC Camargo Cancer Center - São Paulo (SP), Brazil
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  givenname: Ivana Lameiras
  surname: Gibbons
  fullname: Gibbons, Ivana Lameiras
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  givenname: Marina
  surname: Sonagli
  fullname: Sonagli, Marina
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  givenname: Mariana Petaccia de
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10.1016/S0140-6736(89)90619-3
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Issue 2
Keywords Neoplasm metastasis
Melanoma
Therapeutics
Language English
Portuguese
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  year: 2011
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  article-title: Dramatic regression of cutaneous, nodal, and visceral melanoma metastases
  publication-title: J Am Acad Dermatol
  contributor:
    fullname: Damian, DL; Saw, RP
– volume: 174
  start-page: 1141
  year: 2016
  end-page: 1142
  article-title: Topical diphencyprone for the treatment of locoregional intralymphatic melanoma metastases (LIMMs) of the skin. The 5-Year Norwich experience
  publication-title: Br J Dermatol
  contributor:
    fullname: Moncrieff, M; Fadhil, M; Garioch, J
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  year: 2005
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  publication-title: Dermatology
  contributor:
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Snippet Diphencyprone has been reported as a local immunotherapy for cutaneous melanoma metastases. We aim to report cases of melanoma patients treated with...
Diphencyprone has been reported as a local immunotherapy for cutaneous melanoma metastases. We aim to report cases of melanoma patients treated with...
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StartPage 299
SubjectTerms Administration, Cutaneous
Adult
Aged
Aged, 80 and over
Antineoplastic Agents - therapeutic use
Biopsy
Brazil
Communication
Cyclopropanes - therapeutic use
DERMATOLOGY
Female
Humans
Male
Melanoma
Melanoma - drug therapy
Melanoma - pathology
Melanoma - secondary
Middle Aged
Neoplasm metastasis
Skin Neoplasms - drug therapy
Skin Neoplasms - pathology
Skin Neoplasms - secondary
Therapeutics
Treatment Outcome
Young Adult
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Title Diphencyprone as a therapeutic option in cutaneous metastasis of melanoma. A single-institution experience
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