The Role of Reactive Oxygen Species in Arsenic Toxicity

• Published in: Biomolecules (Basel, Switzerland) Vol. 10; no. 2; p. 240
• Main Authors: Hu, Yuxin, Li, Jin, Lou, Bin, Wu, Ruirui, Wang, Gang, Lu, Chunwei, Wang, Huihui, Pi, Jingbo, Xu, Yuanyuan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 05.02.2020; MDPI AG
• Subjects: Animals; antioxidants; Antioxidants - metabolism; Apoptosis - drug effects; arsenic; Arsenic - toxicity; Arsenic Poisoning; Cell Proliferation; Epigenesis, Genetic; Humans; Inflammation; MAP Kinase Signaling System; Mice; MicroRNAs - metabolism; Mitophagy; NF-E2-Related Factor 2 - metabolism; NF-kappa B - metabolism; nrf2; Oxidation-Reduction; Oxidative Stress - drug effects; Phosphorylation; Reactive Oxygen Species - metabolism; Review; ros; signaling pathway; Transcription Factor AP-1 - metabolism; Tumor Suppressor Protein p53 - metabolism; Tyrosine - metabolism; signaling pathway; arsenic; Nrf2; antioxidants; ROS

Arsenic poisoning is a global health problem. Chronic exposure to arsenic has been associated with the development of a wide range of diseases and health problems in humans. Arsenic exposure induces the generation of intracellular reactive oxygen species (ROS), which mediate multiple changes to cell...