The Role of Reactive Oxygen Species in Arsenic Toxicity
Arsenic poisoning is a global health problem. Chronic exposure to arsenic has been associated with the development of a wide range of diseases and health problems in humans. Arsenic exposure induces the generation of intracellular reactive oxygen species (ROS), which mediate multiple changes to cell...
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| Published in | Biomolecules (Basel, Switzerland) Vol. 10; no. 2; p. 240 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
MDPI
05.02.2020
MDPI AG |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Arsenic poisoning is a global health problem. Chronic exposure to arsenic has been associated with the development of a wide range of diseases and health problems in humans. Arsenic exposure induces the generation of intracellular reactive oxygen species (ROS), which mediate multiple changes to cell behavior by altering signaling pathways and epigenetic modifications, or cause direct oxidative damage to molecules. Antioxidants with the potential to reduce ROS levels have been shown to ameliorate arsenic-induced lesions. However, emerging evidence suggests that constructive activation of antioxidative pathways and decreased ROS levels contribute to chronic arsenic toxicity in some cases. This review details the pathways involved in arsenic-induced redox imbalance, as well as current studies on prophylaxis and treatment strategies using antioxidants. |
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| AbstractList | Arsenic poisoning is a global health problem. Chronic exposure to arsenic has been associated with the development of a wide range of diseases and health problems in humans. Arsenic exposure induces the generation of intracellular reactive oxygen species (ROS), which mediate multiple changes to cell behavior by altering signaling pathways and epigenetic modifications, or cause direct oxidative damage to molecules. Antioxidants with the potential to reduce ROS levels have been shown to ameliorate arsenic-induced lesions. However, emerging evidence suggests that constructive activation of antioxidative pathways and decreased ROS levels contribute to chronic arsenic toxicity in some cases. This review details the pathways involved in arsenic-induced redox imbalance, as well as current studies on prophylaxis and treatment strategies using antioxidants. Arsenic poisoning is a global health problem. Chronic exposure to arsenic has been associated with the development of a wide range of diseases and health problems in humans. Arsenic exposure induces the generation of intracellular reactive oxygen species (ROS), which mediate multiple changes to cell behavior by altering signaling pathways and epigenetic modifications, or cause direct oxidative damage to molecules. Antioxidants with the potential to reduce ROS levels have been shown to ameliorate arsenic-induced lesions. However, emerging evidence suggests that constructive activation of antioxidative pathways and decreased ROS levels contribute to chronic arsenic toxicity in some cases. This review details the pathways involved in arsenic-induced redox imbalance, as well as current studies on prophylaxis and treatment strategies using antioxidants.Arsenic poisoning is a global health problem. Chronic exposure to arsenic has been associated with the development of a wide range of diseases and health problems in humans. Arsenic exposure induces the generation of intracellular reactive oxygen species (ROS), which mediate multiple changes to cell behavior by altering signaling pathways and epigenetic modifications, or cause direct oxidative damage to molecules. Antioxidants with the potential to reduce ROS levels have been shown to ameliorate arsenic-induced lesions. However, emerging evidence suggests that constructive activation of antioxidative pathways and decreased ROS levels contribute to chronic arsenic toxicity in some cases. This review details the pathways involved in arsenic-induced redox imbalance, as well as current studies on prophylaxis and treatment strategies using antioxidants. |
| Author | Xu, Yuanyuan Hu, Yuxin Pi, Jingbo Wu, Ruirui Wang, Gang Li, Jin Lu, Chunwei Lou, Bin Wang, Huihui |
| AuthorAffiliation | 1 Experimental Teaching Center, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang 110122, China; yxhu@cmu.edu.cn (Y.H.); gwang@cmu.edu.cn (G.W.); cwlu@cmu.edu.cn (C.L.) 2 Program of Environmental Toxicology, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang 110122, China; L1019Jin@163.com (J.L.); binlougg@gmail.com (B.L.); rui1224984970@163.com (R.W.); hhwang@cmu.edu.cn (H.W.); jbpi@cmu.edu.cn (J.P.) |
| AuthorAffiliation_xml | – name: 1 Experimental Teaching Center, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang 110122, China; yxhu@cmu.edu.cn (Y.H.); gwang@cmu.edu.cn (G.W.); cwlu@cmu.edu.cn (C.L.) – name: 2 Program of Environmental Toxicology, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang 110122, China; L1019Jin@163.com (J.L.); binlougg@gmail.com (B.L.); rui1224984970@163.com (R.W.); hhwang@cmu.edu.cn (H.W.); jbpi@cmu.edu.cn (J.P.) |
| Author_xml | – sequence: 1 givenname: Yuxin orcidid: 0000-0002-2589-3007 surname: Hu fullname: Hu, Yuxin – sequence: 2 givenname: Jin surname: Li fullname: Li, Jin – sequence: 3 givenname: Bin surname: Lou fullname: Lou, Bin – sequence: 4 givenname: Ruirui surname: Wu fullname: Wu, Ruirui – sequence: 5 givenname: Gang surname: Wang fullname: Wang, Gang – sequence: 6 givenname: Chunwei surname: Lu fullname: Lu, Chunwei – sequence: 7 givenname: Huihui surname: Wang fullname: Wang, Huihui – sequence: 8 givenname: Jingbo surname: Pi fullname: Pi, Jingbo – sequence: 9 givenname: Yuanyuan orcidid: 0000-0003-2354-9453 surname: Xu fullname: Xu, Yuanyuan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32033297$$D View this record in MEDLINE/PubMed |
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| Snippet | Arsenic poisoning is a global health problem. Chronic exposure to arsenic has been associated with the development of a wide range of diseases and health... |
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| SubjectTerms | Animals antioxidants Antioxidants - metabolism Apoptosis - drug effects arsenic Arsenic - toxicity Arsenic Poisoning Cell Proliferation Epigenesis, Genetic Humans Inflammation MAP Kinase Signaling System Mice MicroRNAs - metabolism Mitophagy NF-E2-Related Factor 2 - metabolism NF-kappa B - metabolism nrf2 Oxidation-Reduction Oxidative Stress - drug effects Phosphorylation Reactive Oxygen Species - metabolism Review ros signaling pathway Transcription Factor AP-1 - metabolism Tumor Suppressor Protein p53 - metabolism Tyrosine - metabolism |
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| Title | The Role of Reactive Oxygen Species in Arsenic Toxicity |
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