Enhanced radioresponse with a novel recombinant human endostatin protein via tumor vasculature remodeling: Experimental and clinical evidence

• Published in: Radiotherapy and oncology Vol. 106; no. 1; pp. 130 - 137
• Main Authors: Meng, Mao-Bin, Jiang, Xiao-Dong, Deng, Lei, Na, Fei-Fei, He, Jia-Zhuo, Xue, Jian-Xin, Guo, Wen-Hao, Wen, Qing-Lian, Lan, Jie, Mo, Xian-Ming, Lang, Jin-Yi, Lu, You
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.01.2013
• Subjects: Actins - analysis; Actins - genetics; Adolescent; Adult; Aged; Animals; Apoptosis - drug effects; Carcinoma, Non-Small-Cell Lung - blood supply; Carcinoma, Non-Small-Cell Lung - radiotherapy; Cell Hypoxia; Endostatins - pharmacology; Endothelial Cells - physiology; Female; Hematology, Oncology and Palliative Medicine; Humans; Lung Neoplasms - blood supply; Lung Neoplasms - radiotherapy; Mice; Mice, Inbred BALB C; Middle Aged; Platelet Endothelial Cell Adhesion Molecule-1 - genetics; Radiation-Sensitizing Agents - pharmacology; Radiotherapy; Recombinant human endostatin; Recombinant Proteins - pharmacology; RNA, Messenger - analysis; Tumor vasculature remodeling; Tumor vasculature remodeling; Recombinant human endostatin; Radiotherapy

This study aimed to examine the effect of the novel recombinant human endostatin (rh-Endo) protein on tumor vasculature, and to explore and evaluate the optimal scheduling of rh-Endo and radiotherapy (RT). Tumor-perfusion parameters and hypoxia were monitored after rh-Endo treatment in 10 non-small...