Biosignificance of bacterial cyanogenesis in the CF lung

• Published in: Journal of cystic fibrosis Vol. 9; no. 3; pp. 158 - 164
• Main Authors: Anderson, R.D, Roddam, L.F, Bettiol, S, Sanderson, K, Reid, D.W
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2010
• Subjects: Cyanides - immunology; Cyanides - metabolism; Cyanides - toxicity; Cyanogenesis; Cystic fibrosis; Cystic Fibrosis - immunology; Cystic Fibrosis - microbiology; Disease Progression; Host-Pathogen Interactions - immunology; Host-Pathogen Interactions - physiology; Humans; Lung; Lung Diseases - immunology; Lung Diseases - microbiology; Pseudomonas; Pseudomonas aeruginosa - metabolism; Pseudomonas Infections - immunology; Pulmonary/Respiratory; Toxicity; Cyanogenesis; Cystic fibrosis; Pseudomonas; Toxicity; Lung

Abstract Two recent studies have demonstrated the presence of biologically significant amounts of cyanide within the airways of cystic fibrosis (CF) patients infected with Pseudomonas aeruginosa . Whilst environmental strains of P. aeruginosa are known to synthesise cyanide, there has been a relativ...