Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System

• Published in: International journal of radiation oncology, biology, physics Vol. 106; no. 2; pp. 440 - 448
• Main Authors: Diffenderfer, Eric S., Verginadis, Ioannis I., Kim, Michele M., Shoniyozov, Khayrullo, Velalopoulou, Anastasia, Goia, Denisa, Putt, Mary, Hagan, Sarah, Avery, Stephen, Teo, Kevin, Zou, Wei, Lin, Alexander, Swisher-McClure, Samuel, Koch, Cameron, Kennedy, Ann R., Minn, Andy, Maity, Amit, Busch, Theresa M., Dong, Lei, Koumenis, Costas, Metz, James, Cengel, Keith A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2020
• Subjects: Abdomen - radiation effects; Animals; Cell Proliferation - radiation effects; Equipment Design - methods; Feasibility Studies; Female; Fibrosis; Gamma Rays; Intestine, Small - pathology; Intestine, Small - radiation effects; Mice; Mice, Inbred C57BL; Organ Sparing Treatments - instrumentation; Organ Sparing Treatments - methods; Organs at Risk - pathology; Organs at Risk - radiation effects; Pancreatic Neoplasms - radiotherapy; Proton Therapy - instrumentation; Proton Therapy - methods; Radiation Injuries, Experimental - prevention & control; Radiation Protection - instrumentation; Radiation Protection - methods; Radiometry - methods; Radiotherapy, Image-Guided - instrumentation; Radiotherapy, Image-Guided - methods; Scattering, Radiation; Stem Cells - radiation effects; Tomography, X-Ray Computed

Recent studies suggest that ultrahigh-dose-rate, “FLASH,” electron radiation therapy (RT) decreases normal tissue damage while maintaining tumor response compared with conventional dose rate RT. Here, we describe a novel RT apparatus that delivers FLASH proton RT (PRT) using double scattered protons...