Mutational analysis of the mitochondrial 12S rRNA gene in Chinese pediatric subjects with aminoglycoside-induced and non-syndromic hearing loss

• Published in: Human genetics Vol. 117; no. 1; pp. 9 - 15
• Main Authors: Li, Zhiyuan, Li, Ronghua, Chen, Jianfu, Liao, Zhisu, Zhu, Yi, Qian, Yaping, Xiong, Sudao, Heman-Ackah, Selena, Wu, Jianbo, Choo, Daniel I., Guan, Min-Xin
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.06.2005; Berlin Springer Nature B.V; New York, NY
• Subjects: Adolescent; Aminoglycosides - metabolism; Analysis; Antibiotics; Bacterial infections; Biological and medical sciences; Child; China; Classical genetics, quantitative genetics, hybrids; Deafness; DNA Mutational Analysis; DNA, Mitochondrial - genetics; Drugs; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology; Female; Fundamental and applied biological sciences. Psychology; Genes; Genetic aspects; Genetic Predisposition to Disease; Genetic research; Genetics; Genetics of eukaryotes. Biological and molecular evolution; Hearing loss; Hearing Loss - genetics; Hearing protection; Human; Humans; Infections; Male; Medical sciences; Mitochondrial DNA; Mutation; Non tumoral diseases; Otology; Otorhinolaryngology. Stomatology; Pediatrics; Ribonucleic acid; RNA; RNA, Ribosomal - genetics; China; United States > US; Pediatrics; Mitochondria; Gene; Aminoglycoside; Analysis; Auditory disorder; ENT disease; Chinese; Genetics; Mutation; Hearing loss

Mutations in mitochondrial DNA (mtDNA) have been found to be associated with sensorineural hearing loss. We report here a systematic mutational screening of the mitochondrial 12S rRNA gene in 128 Chinese pediatric subjects with sporadic aminoglycoside-induced and non-syndromic hearing loss. We show...