Unique genetic profile of sporadic colorectal cancer liver metastasis versus primary tumors as defined by high-density single-nucleotide polymorphism arrays

• Published in: Modern pathology Vol. 25; no. 4; pp. 590 - 601
• Main Authors: Muñoz-Bellvis, Luís, Fontanillo, Celia, González-González, María, Garcia, Eva, Iglesias, Manuel, Esteban, Carmen, Gutierrez, M L, Abad, M M, Bengoechea, Oscar, De Las Rivas, Javier, Orfao, Alberto, Sayagués, J M
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.04.2012; Elsevier Limited
• Subjects: 631/208/191/2018; 631/208/457/649; 631/67/322; 692/699/67/1504/1885; Adenocarcinoma - chemistry; Adenocarcinoma - genetics; Adenocarcinoma - secondary; Adenoma; Aged; Aged, 80 and over; Arrays; Biomarkers, Tumor - analysis; Biomarkers, Tumor - genetics; Chi-Square Distribution; chromosome 4; chromosome 5; Chromosome Aberrations; Chromosomes; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - chemistry; Colorectal Neoplasms - genetics; Colorectal Neoplasms - pathology; DNA Copy Number Variations; Female; Gene Expression Profiling - methods; Genetic Predisposition to Disease; Hepatocytes; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Laboratory Medicine; Liver; Liver cancer; Liver Neoplasms - chemistry; Liver Neoplasms - genetics; Liver Neoplasms - secondary; Male; Medical prognosis; Medicine; Medicine & Public Health; Metastases; Metastasis; Microenvironments; Microsatellite Repeats; Middle Aged; MLH1 protein; MSH2 protein; MSH6 gene; Neoplasm Invasiveness; Oligonucleotide Array Sequence Analysis; original-article; Pathology; Phenotype; Polymorphism; Polymorphism, Single Nucleotide; Prognosis; Single-nucleotide polymorphism; Spain; Tumors; Spain; FISH; colorectal cancer; SNP array; copy number change; liver metastases

Most genetic studies in colorectal carcinomas have focused on those abnormalities that are acquired by primary tumors, particularly in the transition from adenoma to carcinoma, whereas few studies have compared the genetic abnormalities of primary versus paired metastatic samples. In this study, we...