Design considerations for optogenetic applications of soft micro-LED-based device systems across diverse nervous systems

• Published in: Bioactive materials Vol. 48; pp. 217 - 241
• Main Authors: Lee, Ju Young, Kim, Taemin, Cho, Shinil, Shin, Jiho, Yeo, Woon-Hong, Kim, Tae Soo, Yu, Ki Jun
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.06.2025; KeAi Publishing Communications Ltd; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: Addictive behaviors; Autonomic nervous system; Behavior; Brain research; Closed loops; Design; Devices; Electrical stimuli; Experiments; Feedback control; Genetic modification; Genetics; Information processing; Laser applications; Light emitting diodes; Light sources; Medical research; Medical science; Nervous system; Neural networks; Neural prostheses; Neurological diseases; Neuromodulation; Optics; Review; Somatic nervous system; Spatial discrimination; Spatial resolution; Spinal cord; Waveguides

Optogenetics enables precise, cell-specific control of neural activity, surpassing traditional electrical stimulation methods that indiscriminately activate nearby cells, making it crucial for rehabilitation, neurological disorder treatment, and understanding neural circuits. Among light sources for...