Tools for Understanding Nanoscale Lipid Regulation of Ion Channels

• Published in: Trends in biochemical sciences (Amsterdam. Regular ed.) Vol. 44; no. 9; pp. 795 - 806
• Main Authors: Robinson, Carol V., Rohacs, Tibor, Hansen, Scott B.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2019
• Subjects: cryo-electron microscopy; Humans; ion channels; Ion Channels - metabolism; lipid rafts; mass spectrometry; Nanotechnology; phospholipids; Phospholipids - metabolism; plasma membrane; signaling lipids; super-resolution imaging; lipid rafts; mass spectrometry; super-resolution imaging; signaling lipids; cryo-electron microscopy

Anionic phospholipids are minor but prominent components of the plasma membrane that are necessary for ion channel function. Their persistence in bulk membranes, in particular phosphatidylinositol 4,5-bisphosphate (PIP2), initially suggested they act as channel cofactors. However, recent technologie...