Tools for Understanding Nanoscale Lipid Regulation of Ion Channels
Anionic phospholipids are minor but prominent components of the plasma membrane that are necessary for ion channel function. Their persistence in bulk membranes, in particular phosphatidylinositol 4,5-bisphosphate (PIP2), initially suggested they act as channel cofactors. However, recent technologie...
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| Published in | Trends in biochemical sciences (Amsterdam. Regular ed.) Vol. 44; no. 9; pp. 795 - 806 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.09.2019
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Anionic phospholipids are minor but prominent components of the plasma membrane that are necessary for ion channel function. Their persistence in bulk membranes, in particular phosphatidylinositol 4,5-bisphosphate (PIP2), initially suggested they act as channel cofactors. However, recent technologies have established an emerging system of nanoscale signaling to ion channels based on lipid compartmentalization (clustering), direct lipid binding, and local lipid dynamics that allow cells to harness lipid heterogeneity to gate ion channels. The new tools to study lipid binding are set to transform our view of the membrane and answer important questions surrounding ion channel-delimited processes such as mechanosensation.
Mass spectrometry, cryo-EM, and super-resolution microscopy are advanced tools set to evolve the role of phosphatidylinositol 4,5 bisphosphate (PIP2) and other anionic lipids in the regulation of ion channel function.Cells harness lipid heterogeneity to gate a channel.Phosphatidic acid (PA)-regulated channels are an emerging class of lipid-regulated channels.Nanoscale lipid gradients open up the possibility for membrane-resident anionic lipids to centrally coordinate biological processes by locally regulating ion channel function. |
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| AbstractList | Anionic phospholipids are minor but prominent components of the plasma membrane that are necessary for ion channel function. Their persistence in bulk membranes, in particular phosphatidylinositol 4,5-bisphosphate (PIP2), initially suggested they act as channel cofactors. However, recent technologies have established an emerging system of nanoscale signaling to ion channels based on lipid compartmentalization (clustering), direct lipid binding, and local lipid dynamics that allow cells to harness lipid heterogeneity to gate ion channels. The new tools to study lipid binding are set to transform our view of the membrane and answer important questions surrounding ion channel-delimited processes such as mechanosensation.Anionic phospholipids are minor but prominent components of the plasma membrane that are necessary for ion channel function. Their persistence in bulk membranes, in particular phosphatidylinositol 4,5-bisphosphate (PIP2), initially suggested they act as channel cofactors. However, recent technologies have established an emerging system of nanoscale signaling to ion channels based on lipid compartmentalization (clustering), direct lipid binding, and local lipid dynamics that allow cells to harness lipid heterogeneity to gate ion channels. The new tools to study lipid binding are set to transform our view of the membrane and answer important questions surrounding ion channel-delimited processes such as mechanosensation. Anionic phospholipids are minor but prominent components of the plasma membrane and necessary for ion channel function. Their persistence in bulk membranes, in particular phosphatidylinositol 4,5-bisphosphate (PIP 2 ), initially suggested they act as channel cofactors. However, recent technologies have established an emerging system of nanoscale signaling to ion channels based on lipid compartmentalization (clustering), direct lipid binding, and local lipid dynamics that allow cells to harness lipid heterogeneity to gate ion channels. The new tools to study lipid binding are set to transform our view of the membrane and answer important questions surrounding ion channel delimited processes, such as mechanosensation. Anionic phospholipids are minor but prominent components of the plasma membrane that are necessary for ion channel function. Their persistence in bulk membranes, in particular phosphatidylinositol 4,5-bisphosphate (PIP ), initially suggested they act as channel cofactors. However, recent technologies have established an emerging system of nanoscale signaling to ion channels based on lipid compartmentalization (clustering), direct lipid binding, and local lipid dynamics that allow cells to harness lipid heterogeneity to gate ion channels. The new tools to study lipid binding are set to transform our view of the membrane and answer important questions surrounding ion channel-delimited processes such as mechanosensation. Anionic phospholipids are minor but prominent components of the plasma membrane that are necessary for ion channel function. Their persistence in bulk membranes, in particular phosphatidylinositol 4,5-bisphosphate (PIP2), initially suggested they act as channel cofactors. However, recent technologies have established an emerging system of nanoscale signaling to ion channels based on lipid compartmentalization (clustering), direct lipid binding, and local lipid dynamics that allow cells to harness lipid heterogeneity to gate ion channels. The new tools to study lipid binding are set to transform our view of the membrane and answer important questions surrounding ion channel-delimited processes such as mechanosensation. Anionic phospholipids are minor but prominent components of the plasma membrane that are necessary for ion channel function. Their persistence in bulk membranes, in particular phosphatidylinositol 4,5-bisphosphate (PIP2), initially suggested they act as channel cofactors. However, recent technologies have established an emerging system of nanoscale signaling to ion channels based on lipid compartmentalization (clustering), direct lipid binding, and local lipid dynamics that allow cells to harness lipid heterogeneity to gate ion channels. The new tools to study lipid binding are set to transform our view of the membrane and answer important questions surrounding ion channel-delimited processes such as mechanosensation. Mass spectrometry, cryo-EM, and super-resolution microscopy are advanced tools set to evolve the role of phosphatidylinositol 4,5 bisphosphate (PIP2) and other anionic lipids in the regulation of ion channel function.Cells harness lipid heterogeneity to gate a channel.Phosphatidic acid (PA)-regulated channels are an emerging class of lipid-regulated channels.Nanoscale lipid gradients open up the possibility for membrane-resident anionic lipids to centrally coordinate biological processes by locally regulating ion channel function. |
| Author | Rohacs, Tibor Robinson, Carol V. Hansen, Scott B. |
| AuthorAffiliation | 4 Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458, USA 3 Department of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida 33458, USA 2 Department of Pharmacology, Physiology and Neuroscience, Rutgers - New Jersey Medical School, Newark, NJ 07103, USA 1 Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford, Oxford, UK |
| AuthorAffiliation_xml | – name: 1 Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford, Oxford, UK – name: 2 Department of Pharmacology, Physiology and Neuroscience, Rutgers - New Jersey Medical School, Newark, NJ 07103, USA – name: 4 Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458, USA – name: 3 Department of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida 33458, USA |
| Author_xml | – sequence: 1 givenname: Carol V. surname: Robinson fullname: Robinson, Carol V. organization: Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford, Oxford, UK – sequence: 2 givenname: Tibor surname: Rohacs fullname: Rohacs, Tibor organization: Department of Pharmacology, Physiology and Neuroscience, Rutgers New Jersey Medical School, Newark, NJ 07103, USA – sequence: 3 givenname: Scott B. surname: Hansen fullname: Hansen, Scott B. email: shansen@scripps.edu organization: Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31060927$$D View this record in MEDLINE/PubMed |
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| Keywords | lipid rafts mass spectrometry super-resolution imaging signaling lipids cryo-electron microscopy |
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| SubjectTerms | cryo-electron microscopy Humans ion channels Ion Channels - metabolism lipid rafts mass spectrometry Nanotechnology phospholipids Phospholipids - metabolism plasma membrane signaling lipids super-resolution imaging |
| Title | Tools for Understanding Nanoscale Lipid Regulation of Ion Channels |
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