Phospholipid-Based Artificial Viruses Assembled by Multivalent Cations

• Published in: Biophysical journal Vol. 93; no. 2; pp. 637 - 644
• Main Authors: Tresset, Guillaume, Davy Cheong, Wun Chet, Shireen Tan, Yan Ling, Boulaire, Jérôme, Ming Lam, Yeng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.07.2007; Biophysical Society; The Biophysical Society
• Subjects: Biophysical Phenomena; Biophysics; Cations; Cell Line; Deoxyribonucleic acid; DNA; DNA - chemistry; DNA - genetics; Drug Delivery Systems; Electrostatics; Genetic Therapy; Humans; Ions; Lipids; Macromolecular Substances; Membranes, Artificial; Models, Molecular; Monte Carlo Method; Phospholipids - chemistry; Supramolecular Assemblies; Transfection; Viruses - chemistry

Self-assembled DNA delivery systems based on cationic lipids are simple to produce and weakly hazardous in comparison with viral vectors, but possess a significant toxicity at high doses. Phospholipids are in contrast intrinsically safe; yet their association with DNA is problematic because of unfav...