Epithelial inflammasomes in the defense against Salmonella gut infection

• Published in: Current opinion in microbiology Vol. 59; pp. 86 - 94
• Main Authors: Fattinger, Stefan A, Sellin, Mikael E, Hardt, Wolf-Dietrich
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2021
• Subjects: cell death; enteropathogens; flagellum; inflammasomes; microbiology; Salmonella Typhimurium

•NAIP/NLRC4 and Caspase-4/11 inflammasomes restrict S.Tm infection of gut epithelium.•Importance of NAIP/NLRC4 versus Caspase-4/11 may shift between early and late infection.•Cell state and species-specific differences affect IEC inflammasome defense.•Interconnected inflammasome signalling may lead...