Synthesis and evaluation of antimigratory and antiproliferative activities of lipid-linked [13]-macro-dilactones

• Published in: Bioorganic & medicinal chemistry letters Vol. 20; no. 18; pp. 5472 - 5476
• Main Authors: Magpusao, Anniefer N., Desmond, Richard T., Billings, Katelyn J., Fenteany, Gabriel, Peczuh, Mark W.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 15.09.2010; Elsevier
• Subjects: Antineoplastic agents; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biological and medical sciences; Cancer; Cell growth; Cell Line, Tumor; Cell migration; Cell Movement - drug effects; Cell Proliferation - drug effects; General aspects; Glucosides - chemical synthesis; Glucosides - chemistry; Glucosides - pharmacology; Humans; Inhibitors; Lactones - chemical synthesis; Lactones - chemistry; Lactones - pharmacology; Lipids - chemistry; Macro-dilactones; Medical sciences; Migrastatin; Neoplasms - drug therapy; Octyl glucoside; Pharmacology. Drug treatments; Structure-Activity Relationship; Migrastatin; Cell growth; Octyl glucoside; Inhibitors; Cell migration; Macro-dilactones; Antineoplastic agent; Human; Aldose; Glucoside; Cytotoxicity; Antimetastatic agent; Oxygen heterocycle; In vitro; Macrolide; Cell line; Structure activity relation; Bicyclic compound; Glycoside; Mammary gland; Chemical synthesis; Tumor cell

The biological activities of a family of novel, lipid-linked 13-membered-ring macro-dilactones are reported. These [13]-macro-dilactones were synthesized by diacylation of functionalized diols, followed by ring-closing metathesis under conditions we had previously reported. Antimigratory, cytostatic...