Development of clinical signs in low risk term born infants with neonatal hyperexcitability

Several studies have reported on neonatal tremors or “jitteriness” or, as described by Precthl “hyperexcitability syndrome” including tremors and increased resistance to passive movement. To describe the evolution of signs and the outcome at one year in low risk term born infants with neonatal tremo...

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Published in	Early human development Vol. 89; no. 2; pp. 65 - 68
Main Authors	Leone, Daniela, Brogna, Claudia, Ricci, Daniela, Romeo, Domenico M., Leo, Giuseppina, Serrao, Francesca, Gallini, Francesca, Cioni, Giovanni, Romagnoli, Costantino, Mercuri, Eugenio
Format	Journal Article
Language	English
Published	Amsterdam Elsevier Ireland Ltd 01.02.2013 Elsevier
Subjects	Advanced Basic Science Biological and medical sciences Embryology: invertebrates and vertebrates. Teratology Fundamental and applied biological sciences. Psychology Gestational Age Humans Infant Infant, Newborn Longitudinal Studies Neonatal and Perinatal Medicine Neurologic Examination Prognosis Risk Factors Tremor - diagnosis Tremor - physiopathology Human Development Infant Neonatal Hyperexcitability
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Abstract	Several studies have reported on neonatal tremors or “jitteriness” or, as described by Precthl “hyperexcitability syndrome” including tremors and increased resistance to passive movement. To describe the evolution of signs and the outcome at one year in low risk term born infants with neonatal tremors persisting beyond 10days. 84 low risk term born neonates with tremors at birth and persisting after 10days, underwent a longitudinal neurological assessment paying attention to the evolution of tremors and increased resistance to passive movement. At 1month 74 of the 84 infants had persistent tremors, isolated in 27 or associated with increased resistance to passive movement in the other 47. The remaining 10 had isolated increased resistance to passive movement and none had a normal assessment. The percentage of infants with a normal assessment progressively increased at 6, 9 and 12months (34.5%, 77%, 93% respectively). Our data suggest that neonatal tremors can have a variable evolution and rate of resolution, with 70% of recovery by 9months with a normal outcome at 24months in all. The risk of persistence of signs (at 12months) in infants with either isolated tremors or increased resistance to passive movements is lower than in the subgroup with both signs at one month.
AbstractList	Several studies have reported on neonatal tremors or “jitteriness” or, as described by Precthl “hyperexcitability syndrome” including tremors and increased resistance to passive movement. To describe the evolution of signs and the outcome at one year in low risk term born infants with neonatal tremors persisting beyond 10days. 84 low risk term born neonates with tremors at birth and persisting after 10days, underwent a longitudinal neurological assessment paying attention to the evolution of tremors and increased resistance to passive movement. At 1month 74 of the 84 infants had persistent tremors, isolated in 27 or associated with increased resistance to passive movement in the other 47. The remaining 10 had isolated increased resistance to passive movement and none had a normal assessment. The percentage of infants with a normal assessment progressively increased at 6, 9 and 12months (34.5%, 77%, 93% respectively). Our data suggest that neonatal tremors can have a variable evolution and rate of resolution, with 70% of recovery by 9months with a normal outcome at 24months in all. The risk of persistence of signs (at 12months) in infants with either isolated tremors or increased resistance to passive movements is lower than in the subgroup with both signs at one month. Several studies have reported on neonatal tremors or "jitteriness" or, as described by Precthl "hyperexcitability syndrome" including tremors and increased resistance to passive movement. To describe the evolution of signs and the outcome at one year in low risk term born infants with neonatal tremors persisting beyond 10 days. 84 low risk term born neonates with tremors at birth and persisting after 10 days, underwent a longitudinal neurological assessment paying attention to the evolution of tremors and increased resistance to passive movement. At 1 month 74 of the 84 infants had persistent tremors, isolated in 27 or associated with increased resistance to passive movement in the other 47. The remaining 10 had isolated increased resistance to passive movement and none had a normal assessment. The percentage of infants with a normal assessment progressively increased at 6, 9 and 12 months (34.5%, 77%, 93% respectively). Our data suggest that neonatal tremors can have a variable evolution and rate of resolution, with 70% of recovery by 9 months with a normal outcome at 24 months in all. The risk of persistence of signs (at 12 months) in infants with either isolated tremors or increased resistance to passive movements is lower than in the subgroup with both signs at one month. Several studies have reported on neonatal tremors or "jitteriness" or, as described by Precthl "hyperexcitability syndrome" including tremors and increased resistance to passive movement.BACKGROUNDSeveral studies have reported on neonatal tremors or "jitteriness" or, as described by Precthl "hyperexcitability syndrome" including tremors and increased resistance to passive movement.To describe the evolution of signs and the outcome at one year in low risk term born infants with neonatal tremors persisting beyond 10 days.AIMTo describe the evolution of signs and the outcome at one year in low risk term born infants with neonatal tremors persisting beyond 10 days.84 low risk term born neonates with tremors at birth and persisting after 10 days, underwent a longitudinal neurological assessment paying attention to the evolution of tremors and increased resistance to passive movement.SUBJECTS84 low risk term born neonates with tremors at birth and persisting after 10 days, underwent a longitudinal neurological assessment paying attention to the evolution of tremors and increased resistance to passive movement.At 1 month 74 of the 84 infants had persistent tremors, isolated in 27 or associated with increased resistance to passive movement in the other 47. The remaining 10 had isolated increased resistance to passive movement and none had a normal assessment. The percentage of infants with a normal assessment progressively increased at 6, 9 and 12 months (34.5%, 77%, 93% respectively).RESULTSAt 1 month 74 of the 84 infants had persistent tremors, isolated in 27 or associated with increased resistance to passive movement in the other 47. The remaining 10 had isolated increased resistance to passive movement and none had a normal assessment. The percentage of infants with a normal assessment progressively increased at 6, 9 and 12 months (34.5%, 77%, 93% respectively).Our data suggest that neonatal tremors can have a variable evolution and rate of resolution, with 70% of recovery by 9 months with a normal outcome at 24 months in all. The risk of persistence of signs (at 12 months) in infants with either isolated tremors or increased resistance to passive movements is lower than in the subgroup with both signs at one month.CONCLUSIONOur data suggest that neonatal tremors can have a variable evolution and rate of resolution, with 70% of recovery by 9 months with a normal outcome at 24 months in all. The risk of persistence of signs (at 12 months) in infants with either isolated tremors or increased resistance to passive movements is lower than in the subgroup with both signs at one month. Abstract Background Several studies have reported on neonatal tremors or “jitteriness” or, as described by Precthl “hyperexcitability syndrome” including tremors and increased resistance to passive movement. Aim To describe the evolution of signs and the outcome at one year in low risk term born infants with neonatal tremors persisting beyond 10 days. Subjects 84 low risk term born neonates with tremors at birth and persisting after 10 days, underwent a longitudinal neurological assessment paying attention to the evolution of tremors and increased resistance to passive movement. Results At 1 month 74 of the 84 infants had persistent tremors, isolated in 27 or associated with increased resistance to passive movement in the other 47. The remaining 10 had isolated increased resistance to passive movement and none had a normal assessment. The percentage of infants with a normal assessment progressively increased at 6, 9 and 12 months (34.5%, 77%, 93% respectively). Conclusion Our data suggest that neonatal tremors can have a variable evolution and rate of resolution, with 70% of recovery by 9 months with a normal outcome at 24 months in all. The risk of persistence of signs (at 12 months) in infants with either isolated tremors or increased resistance to passive movements is lower than in the subgroup with both signs at one month.
Author	Serrao, Francesca Leo, Giuseppina Gallini, Francesca Romagnoli, Costantino Leone, Daniela Cioni, Giovanni Brogna, Claudia Ricci, Daniela Romeo, Domenico M. Mercuri, Eugenio
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Snippet	Several studies have reported on neonatal tremors or “jitteriness” or, as described by Precthl “hyperexcitability syndrome” including tremors and increased... Abstract Background Several studies have reported on neonatal tremors or “jitteriness” or, as described by Precthl “hyperexcitability syndrome” including... Several studies have reported on neonatal tremors or "jitteriness" or, as described by Precthl "hyperexcitability syndrome" including tremors and increased...
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SubjectTerms	Advanced Basic Science Biological and medical sciences Embryology: invertebrates and vertebrates. Teratology Fundamental and applied biological sciences. Psychology Gestational Age Humans Infant Infant, Newborn Longitudinal Studies Neonatal and Perinatal Medicine Neurologic Examination Prognosis Risk Factors Tremor - diagnosis Tremor - physiopathology
Title	Development of clinical signs in low risk term born infants with neonatal hyperexcitability
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