Effects of esophageal acid infusion vs mosapride on distension‐induced secondary peristalsis in humans

• Published in: The Kaohsiung journal of medical sciences Vol. 35; no. 5; pp. 310 - 314
• Main Authors: Lei, Wei‐Yi, Hung, Jui‐Sheng, Yi, Chih‐Hsun, Liu, Tso‐Tsai, Wong, Ming‐Wun, Chen, Chien‐Lin
• Format: Journal Article
• Language: English
• Published: BP, Asia Wiley Publishing Asia Pty Ltd 01.05.2019; John Wiley & Sons, Inc
• Subjects: 5‐HT4 receptors; Acidification; Administration, Intranasal; Adult; Benzamides - administration & dosage; Catheters; Complications and side effects; Dosage and administration; esophageal peristalsis; Esophagus; Esophagus - drug effects; Esophagus - physiology; Female; Gastrointestinal Agents - administration & dosage; HCl; Healthy Volunteers; Humans; Hydrochloric Acid - administration & dosage; Male; Manometry; Morpholines - administration & dosage; mosapride; Motility; Original; Peristalsis; Peristalsis - drug effects; Peristalsis - physiology; Physiology; Receptors, Serotonin - metabolism; Risk factors; secondary peristalsis; Serotonin agonists; Serotonin Receptor Agonists - administration & dosage; Values; Taiwan; HCl; mosapride; secondary peristalsis; 5-HT4 receptors; esophageal peristalsis

Secondary peristalsis contributes to the clearance of the refluxate from the esophagus. Acute administration of 5‐hydroxytryptamine 4 (5‐HT4) receptors agonist, mosapride or esophageal infusion of hydrochloric acid (HCl) facilitates secondary peristalsis. The aim of this study was to determine wheth...