Design and Analysis of Arm-in-Cage Experiments: Inference for Three-State Progressive Disease Models with Common Periodic Observation Times

• Published in: Biometrics Vol. 64; no. 2; pp. 337 - 344
• Main Authors: Griffin, B. A., Lagakos, S. W.
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.06.2008; Blackwell Publishing; Blackwell Publishing Ltd
• Subjects: Arm-in-cage experiments; Biometric Methodology; Biometrics; biometry; Bites and stings; cages; Censored data; Censorship; Computer Simulation; Cumulative distribution functions; Data Interpretation, Statistical; Design analysis; Design of experiments; Disease models; Disease Progression; Distribution functions; Effectiveness; Experiment design; Humans; Insect Bites and Stings - epidemiology; Insect Bites and Stings - prevention & control; insect repellents; Insect Repellents - administration & dosage; Insect vectors; insects; Interval censoring; Models, Biological; Nonparametric methods; Parametric methods; Pest control; Prevalence; Product testing; Research Design; Sample Size; Statistical analysis; Three-state progressive disease model; Time-to-event data

We develop statistical methods for designing and analyzing arm-in-cage experiments used to test the efficacy of insect repellents and other topical treatments. In these experiments, a controlled amount of the treatment is applied to a volunteer's forearm, which then is exposed to the insects by...