Fibrinogen is chemotactic for vascular smooth muscle cells

• Published in: FEBS letters Vol. 247; no. 2; pp. 358 - 360
• Main Authors: Naito, Michitaka, Hayashi, Toshio, Kuzuya, Masafumi, Funaki, Chiaki, Asai, Kanichi, Kuzuya, Fumio
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 24.04.1989; Elsevier
• Subjects: Animals; Aorta, Thoracic; Atherosclerosis; Biological and medical sciences; Blood coagulation. Blood cells; Cattle; Cells, Cultured; Chemotaxis; Chemotaxis - drug effects; Coagulation factors; Dose-Response Relationship, Drug; Fibrinogen; Fibrinogen - metabolism; Fibrinogen - pharmacology; Fibrinolysin - metabolism; Fundamental and applied biological sciences. Psychology; Intimal thickening; Molecular and cellular biology; Muscle, Smooth, Vascular - physiology; Smooth muscle cell; Trypsin - metabolism; Smooth muscle cell; Intimal thickening; Chemotaxis; Fibrinogen; Atherosclerosis; Cell culture; Vertebrata; Mammalia; Bovine; Gel electrophoresis; Pathogenesis; Muscle; Artiodactyla; Coagulation factor; Ungulata

We studied the effect of fibrinogen on the migration of bovine aortic smooth muscle cells in culture, using a Neuro Probe 48-well micro chemotaxis chamber. Fibrinogen stimulated the migration of the cells dose-dependently at concentrations from 30 to 1OOO μg/ml. A modified checkerboard analysis of t...