Low-grade systemic inflammation in patients with amyotrophic lateral sclerosis
Objective – To prospectively determine the intensity of systemic low‐grade inflammation in patients with amyotrophic lateral sclerosis (ALS). Patients and methods – Patients with ALS and matched healthy controls underwent blood tests for inflammation‐sensitive biomarkers: erythrocyte sedimentation...
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| Published in | Acta neurologica Scandinavica Vol. 119; no. 6; pp. 383 - 389 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.06.2009
Blackwell |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Objective – To prospectively determine the intensity of systemic low‐grade inflammation in patients with amyotrophic lateral sclerosis (ALS).
Patients and methods – Patients with ALS and matched healthy controls underwent blood tests for inflammation‐sensitive biomarkers: erythrocyte sedimentation rate (ESR), quantitative fibrinogen, wide‐range C‐reactive protein (wrCRP) concentrations, leukocyte count and neutrophil‐to‐lymphocyte ratio (NLR). The correlation between these inflammatory biomarkers and disability status of the patients, expressed by the ALS Functional Rating Scale (ALSFRS‐R), was evaluated.
Results – Eighty patients with ALS and 80 matched controls were included. wrCRP, fibrinogen, ESR and NLR values were significantly elevated in patients compared with controls. There was a significant correlation between the ALSFRS‐R score and wrCRP, ESR and fibrinogen levels. This correlation persisted on sequential examinations.
Conclusions – A systemic low‐grade inflammation was detected in patients with ALS and correlated with their degree of disability. A heightened systemic inflammatory state is apparently associated with a negative prognosis in ALS. |
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| AbstractList | Objective – To prospectively determine the intensity of systemic low‐grade inflammation in patients with amyotrophic lateral sclerosis (ALS).
Patients and methods – Patients with ALS and matched healthy controls underwent blood tests for inflammation‐sensitive biomarkers: erythrocyte sedimentation rate (ESR), quantitative fibrinogen, wide‐range C‐reactive protein (wrCRP) concentrations, leukocyte count and neutrophil‐to‐lymphocyte ratio (NLR). The correlation between these inflammatory biomarkers and disability status of the patients, expressed by the ALS Functional Rating Scale (ALSFRS‐R), was evaluated.
Results – Eighty patients with ALS and 80 matched controls were included. wrCRP, fibrinogen, ESR and NLR values were significantly elevated in patients compared with controls. There was a significant correlation between the ALSFRS‐R score and wrCRP, ESR and fibrinogen levels. This correlation persisted on sequential examinations.
Conclusions – A systemic low‐grade inflammation was detected in patients with ALS and correlated with their degree of disability. A heightened systemic inflammatory state is apparently associated with a negative prognosis in ALS. To prospectively determine the intensity of systemic low-grade inflammation in patients with amyotrophic lateral sclerosis (ALS). Patients with ALS and matched healthy controls underwent blood tests for inflammation-sensitive biomarkers: erythrocyte sedimentation rate (ESR), quantitative fibrinogen, wide-range C-reactive protein (wrCRP) concentrations, leukocyte count and neutrophil-to-lymphocyte ratio (NLR). The correlation between these inflammatory biomarkers and disability status of the patients, expressed by the ALS Functional Rating Scale (ALSFRS-R), was evaluated. Eighty patients with ALS and 80 matched controls were included. wrCRP, fibrinogen, ESR and NLR values were significantly elevated in patients compared with controls. There was a significant correlation between the ALSFRS-R score and wrCRP, ESR and fibrinogen levels. This correlation persisted on sequential examinations. A systemic low-grade inflammation was detected in patients with ALS and correlated with their degree of disability. A heightened systemic inflammatory state is apparently associated with a negative prognosis in ALS. OBJECTIVETo prospectively determine the intensity of systemic low-grade inflammation in patients with amyotrophic lateral sclerosis (ALS).PATIENTS AND METHODSPatients with ALS and matched healthy controls underwent blood tests for inflammation-sensitive biomarkers: erythrocyte sedimentation rate (ESR), quantitative fibrinogen, wide-range C-reactive protein (wrCRP) concentrations, leukocyte count and neutrophil-to-lymphocyte ratio (NLR). The correlation between these inflammatory biomarkers and disability status of the patients, expressed by the ALS Functional Rating Scale (ALSFRS-R), was evaluated.RESULTSEighty patients with ALS and 80 matched controls were included. wrCRP, fibrinogen, ESR and NLR values were significantly elevated in patients compared with controls. There was a significant correlation between the ALSFRS-R score and wrCRP, ESR and fibrinogen levels. This correlation persisted on sequential examinations.CONCLUSIONSA systemic low-grade inflammation was detected in patients with ALS and correlated with their degree of disability. A heightened systemic inflammatory state is apparently associated with a negative prognosis in ALS. Keizman D, Rogowski O, Berliner S, Ish-Shalom M, Maimon N, Nefussy B, Artamonov I, Drory VE. Low-grade systemic inflammation in patients with amyotrophic lateral sclerosis. Acta Neurol Scand: DOI: 10.1111-j.1600-0404.2008.01112.x. [copy ] 2008 The Authors Journal compilation [copy ] 2008 Blackwell Munksgaard.Objective - To prospectively determine the intensity of systemic low-grade inflammation in patients with amyotrophic lateral sclerosis (ALS).Patients and methods - Patients with ALS and matched healthy controls underwent blood tests for inflammation-sensitive biomarkers: erythrocyte sedimentation rate (ESR), quantitative fibrinogen, wide-range C-reactive protein (wrCRP) concentrations, leukocyte count and neutrophil-to-lymphocyte ratio (NLR). The correlation between these inflammatory biomarkers and disability status of the patients, expressed by the ALS Functional Rating Scale (ALSFRS-R), was evaluated.Results - Eighty patients with ALS and 80 matched controls were included. wrCRP, fibrinogen, ESR and NLR values were significantly elevated in patients compared with controls. There was a significant correlation between the ALSFRS-R score and wrCRP, ESR and fibrinogen levels. This correlation persisted on sequential examinations.Conclusions - A systemic low-grade inflammation was detected in patients with ALS and correlated with their degree of disability. A heightened systemic inflammatory state is apparently associated with a negative prognosis in ALS. |
| Author | Drory, V. E. Ish-Shalom, M. Rogowski, O. Keizman, D. Berliner, S. Artamonov, I. Nefussy, B. Maimon, N. |
| Author_xml | – sequence: 1 givenname: D. surname: Keizman fullname: Keizman, D. organization: Departments of Oncology – sequence: 2 givenname: O. surname: Rogowski fullname: Rogowski, O. organization: Internal Medicine D – sequence: 3 givenname: S. surname: Berliner fullname: Berliner, S. organization: Internal Medicine E – sequence: 4 givenname: M. surname: Ish-Shalom fullname: Ish-Shalom, M. organization: Internal Medicine H – sequence: 5 givenname: N. surname: Maimon fullname: Maimon, N. organization: Departments of Oncology – sequence: 6 givenname: B. surname: Nefussy fullname: Nefussy, B. organization: Neurology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel – sequence: 7 givenname: I. surname: Artamonov fullname: Artamonov, I. organization: Neurology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel – sequence: 8 givenname: V. E. surname: Drory fullname: Drory, V. E. organization: Neurology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel |
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| Keywords | Human Nervous system diseases C-reactive protein Central nervous system disease Motor neuron disease Amyotrophic lateral sclerosis Degenerative disease Inflammation systemic low-grade inflammation Spinal cord disease Protein |
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| Snippet | Objective – To prospectively determine the intensity of systemic low‐grade inflammation in patients with amyotrophic lateral sclerosis (ALS).
Patients and... To prospectively determine the intensity of systemic low-grade inflammation in patients with amyotrophic lateral sclerosis (ALS). Patients with ALS and matched... Keizman D, Rogowski O, Berliner S, Ish-Shalom M, Maimon N, Nefussy B, Artamonov I, Drory VE. Low-grade systemic inflammation in patients with amyotrophic... OBJECTIVETo prospectively determine the intensity of systemic low-grade inflammation in patients with amyotrophic lateral sclerosis (ALS).PATIENTS AND... |
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| SubjectTerms | Adult Aged Aged, 80 and over amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - blood Amyotrophic Lateral Sclerosis - complications Amyotrophic Lateral Sclerosis - physiopathology Biological and medical sciences Biomarkers - blood Blood Sedimentation C-reactive protein C-Reactive Protein - analysis Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Progression Female Fibrinogen - analysis Humans Inflammation - blood Inflammation - etiology Inflammation - physiopathology Leukocyte Count Male Medical sciences Middle Aged motor neuron disease Neurology Prognosis systemic low-grade inflammation |
| Title | Low-grade systemic inflammation in patients with amyotrophic lateral sclerosis |
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