Strong Negative Interference by Calcium Dobesilate in Sarcosine Oxidase Assays for Serum Creatinine Involving the Trinder Reaction

• Published in: Medicine (Baltimore) Vol. 94; no. 23; p. e905
• Main Authors: Guo, Xiuzhi, Hou, Li’an, Cheng, Xinqi, Zhang, Tianjiao, Yu, Songlin, Fang, Huiling, Xia, Liangyu, Qi, Zhihong, Qin, Xuzhen, Zhang, Lin, Liu, Qian, Liu, Li, Chi, Shuling, Hao, Yingying, Qiu, Ling
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc. All rights reserved 01.06.2015; Wolters Kluwer Health
• Subjects: Adult; Calcium Dobesilate - pharmacology; Clinical Enzyme Tests; Creatinine - blood; Female; Humans; Male; Middle Aged; Observational Study; Sarcosine Oxidase - blood; Sarcosine Oxidase - drug effects; Young Adult

The vasoprotective drug calcium dobesilate is known to interfere with creatinine (Cr) quantifications in sarcosine oxidase enzymatic (SOE) assays. The aim of this study was to investigate this interference in 8 different commercially available assays and to determine its clinical significance. In in...