Missense mutations at ALA‐10 in the factor IX propeptide: an insignificant variant in normal life but a decisive cause of bleeding during oral anticoagulant therapy
Bleeding complications are the most common and unwanted side‐effect of oral anticoagulant therapy. We report three patients in whom mutations in the factor IX (FIX) propeptide were found to cause severe bleeding during coumarin therapy. Strikingly, the bleeding occurred within the therapeutic ranges...
Saved in:
Published in | British journal of haematology Vol. 98; no. 1; pp. 240 - 244 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Science Ltd
01.07.1997
Blackwell |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Bleeding complications are the most common and unwanted side‐effect of oral anticoagulant therapy. We report three patients in whom mutations in the factor IX (FIX) propeptide were found to cause severe bleeding during coumarin therapy. Strikingly, the bleeding occurred within the therapeutic ranges of the prothrombin time (PT) and international normalized ratio (INR). In all three patients coumarin therapy caused an unusually selective decrease of FIX activity (FIX:C) to levels below 1–3%. Upon withdrawal of coumarin, FIX:C increased to subnormal or normal values of 55%, 85% and 125%, respectively. Analysis of the FIX gene revealed two different missense mutations affecting the Ala‐10 residue in the propeptide coding region: Ala[GCC] to Val[GTC] in two patients and Ala[GCC] to Thr[ACC] in one patient. No further mutation was detected by screening 195 random blood donors for mutations at Ala‐10, thus excluding a frequent polymorphism at this position. The mutation in the FIX propeptide at a position which is essential for the carboxylase recognition site causes a reduced affinity of the carboxylase enzyme to the propeptide. This effect leads to an impaired carboxylase epoxidase reaction which is decisively triggered by the vitamin K concentration. Determination of FIX and APTT in addition to PT and INR is therefore recommended in coumarin‐treated patients with an uncommon bleeding pattern. |
---|---|
AbstractList | Bleeding complications are the most common and unwanted side‐effect of oral anticoagulant therapy. We report three patients in whom mutations in the factor IX (FIX) propeptide were found to cause severe bleeding during coumarin therapy. Strikingly, the bleeding occurred within the therapeutic ranges of the prothrombin time (PT) and international normalized ratio (INR). In all three patients coumarin therapy caused an unusually selective decrease of FIX activity (FIX:C) to levels below 1–3%. Upon withdrawal of coumarin, FIX:C increased to subnormal or normal values of 55%, 85% and 125%, respectively. Analysis of the FIX gene revealed two different missense mutations affecting the Ala‐10 residue in the propeptide coding region: Ala[GCC] to Val[GTC] in two patients and Ala[GCC] to Thr[ACC] in one patient. No further mutation was detected by screening 195 random blood donors for mutations at Ala‐10, thus excluding a frequent polymorphism at this position. The mutation in the FIX propeptide at a position which is essential for the carboxylase recognition site causes a reduced affinity of the carboxylase enzyme to the propeptide. This effect leads to an impaired carboxylase epoxidase reaction which is decisively triggered by the vitamin K concentration. Determination of FIX and APTT in addition to PT and INR is therefore recommended in coumarin‐treated patients with an uncommon bleeding pattern. |
Author | Quenzel, Ernst‐Markus Harbrecht, Uschi Fregin, Andreas Hertfelder, Hans‐Jörg Hanfland, Peter Oldenburg, Johannes Müller, Clemens Rainer Kress, Wolfram Brackmann, Hans‐Hermann Schwaab, Rainer |
Author_xml | – sequence: 1 givenname: Johannes surname: Oldenburg fullname: Oldenburg, Johannes – sequence: 2 givenname: Ernst‐Markus surname: Quenzel fullname: Quenzel, Ernst‐Markus – sequence: 3 givenname: Uschi surname: Harbrecht fullname: Harbrecht, Uschi – sequence: 4 givenname: Andreas surname: Fregin fullname: Fregin, Andreas – sequence: 5 givenname: Wolfram surname: Kress fullname: Kress, Wolfram – sequence: 6 givenname: Clemens Rainer surname: Müller fullname: Müller, Clemens Rainer – sequence: 7 givenname: Hans‐Jörg surname: Hertfelder fullname: Hertfelder, Hans‐Jörg – sequence: 8 givenname: Rainer surname: Schwaab fullname: Schwaab, Rainer – sequence: 9 givenname: Hans‐Hermann surname: Brackmann fullname: Brackmann, Hans‐Hermann – sequence: 10 givenname: Peter surname: Hanfland fullname: Hanfland, Peter |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2750554$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/9233593$$D View this record in MEDLINE/PubMed |
BookMark | eNqVUc1u1DAYtFBR2RYeAclCiFuCf2Kn6QFpqYAWLeICEjfLsb8sXmXtYCele-MReAoejCfB0UZ7Rz6MrJn55rPnAp354AGhF5SUlFTy9a6kXIqC0YqWtGnqkjHKCZflwyO0OlFnaEUIqYtsuXqCLlLaEZJlgp6j84ZxLhq-Qn8-uZTAJ8D7adSjCz5hPeL1Zv33129KsPN4_A6402YMEd99w0MMAwyjs3CNtc98clvvOme0H_G9jm7G7PIh7nWPe9cBbqcRa2zBuOTuARs95bzQ4bYHsM5vsZ3iDCFmR_Y7E_R26udJOTzq4fAUPe50n-DZgpfo6_t3X25ui83nD3c3601hBJW04MyIKypaLWjXSmE48IpWrGsq04GpbGWlsfm0bS0aBsyyikhpaGusJLq1_BK9Os7Nz_wxQRrV3iUDfd4FwpRU3VAhm4Zk4fVRaGJIKUKnhuj2Oh4UJWouSe3U3ISam1BzSWopST1k8_MlZWr3YE_WpZXMv1x4nYzuu6h9_rqTjNWCCFFl2Zuj7Kfr4fAfC6i3H2_nyz-6LLMi |
CODEN | BJHEAL |
CitedBy_id | crossref_primary_10_1146_annurev_nutr_25_050304_092713 crossref_primary_10_1016_j_thromres_2011_06_017 crossref_primary_10_1378_chest_08_0670 crossref_primary_10_1097_MJT_0000000000000077 crossref_primary_10_1111_jth_12244 crossref_primary_10_1016_j_thromres_2018_12_005 crossref_primary_10_1074_jbc_274_24_16940 crossref_primary_10_1007_s00277_018_3264_2 crossref_primary_10_1186_s40001_021_00533_7 crossref_primary_10_5482_ha_1151 crossref_primary_10_1016_j_cll_2009_04_001 crossref_primary_10_1007_s00277_018_3398_2 crossref_primary_10_1161_01_STR_0000115528_53718_1B crossref_primary_10_1016_S0889_8588_05_70137_4 crossref_primary_10_1021_bi981031y crossref_primary_10_1111_j_1365_2516_2009_02115_x crossref_primary_10_1136_jcp_2003_008904 crossref_primary_10_1160_TH11_03_0191 crossref_primary_10_1111_j_1365_2141_2007_06784_x crossref_primary_10_1182_blood_2002_06_1753 crossref_primary_10_1046_j_1365_2141_2001_03186_x crossref_primary_10_1055_a_1191_7198 crossref_primary_10_1182_asheducation_2006_1_467 crossref_primary_10_1007_s11239_007_0104_y crossref_primary_10_1111_j_1538_7836_2005_01427_x crossref_primary_10_1007_s11239_011_0580_y crossref_primary_10_1161_01_CIR_0000063575_17904_4E crossref_primary_10_1021_bi991544k crossref_primary_10_1016_j_hoc_2004_09_006 crossref_primary_10_1038_sj_tpj_6500182 crossref_primary_10_1097_01_mbc_0000191522_32353_17 crossref_primary_10_1007_s00228_010_0857_7 crossref_primary_10_1016_j_blre_2007_11_004 crossref_primary_10_1016_S0304_5412_01_70534_3 crossref_primary_10_1378_chest_126_3_suppl_204S crossref_primary_10_1182_blood_V96_5_1816 crossref_primary_10_1046_j_1365_2796_1998_00252_x crossref_primary_10_1046_j_1365_2141_2000_01901_x crossref_primary_10_1016_S1131_3587_12_70050_X crossref_primary_10_1182_blood_V96_5_1816_h8001816_1816_1819 crossref_primary_10_1016_S0140_6736_98_00326_2 crossref_primary_10_1182_blood_V93_6_1798_406k22_1798_1808 crossref_primary_10_5482_HAMO_13_09_0047 crossref_primary_10_1074_jbc_M110_143297 crossref_primary_10_1016_S0735_1097_03_00416_9 crossref_primary_10_1002__SICI_1098_2825_2000_14_3_101__AID_JCLA4_3_0_CO_2_A crossref_primary_10_1016_j_apcatb_2012_04_015 crossref_primary_10_1002_jgm_292 crossref_primary_10_1016_S0140_6736_03_14296_1 crossref_primary_10_1097_00001721_200009000_00005 crossref_primary_10_1046_j_1365_2516_1998_440350_x crossref_primary_10_1378_chest_119_1_suppl_8S crossref_primary_10_1007_BF03041031 crossref_primary_10_1074_jbc_M312239200 |
ContentType | Journal Article |
Copyright | 1997 INIST-CNRS |
Copyright_xml | – notice: 1997 INIST-CNRS |
DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1046/j.1365-2141.1997.2213036.x |
DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE MEDLINE - Academic CrossRef |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1365-2141 |
EndPage | 244 |
ExternalDocumentID | 10_1046_j_1365_2141_1997_2213036_x 9233593 2750554 BJH221 |
Genre | article Research Support, Non-U.S. Gov't Journal Article Case Reports |
GroupedDBID | --- .3N .55 .GA .GJ .Y3 05W 0R~ 10A 1KJ 1OB 1OC 23N 24P 31~ 33P 36B 3O- 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 6J9 6P2 702 7PT 8-0 8-1 8-3 8-4 8-5 8F7 8UM 930 A01 A03 AAESR AAEVG AAHHS AAKAS AANLZ AAONW AASGY AAXRX AAYEP AAZKR ABCQN ABCUV ABEML ABJNI ABLJU ABOCM ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACFBH ACGFO ACGFS ACGOF ACMXC ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZCM ADZMN ADZOD AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFNX AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AHEFC AI. AIACR AIAGR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EBS EGARE EJD EMOBN ESX EX3 F00 F01 F04 F5P FEDTE FUBAC FZ0 G-S G.N GODZA H.X HF~ HGLYW HVGLF HZI HZ~ IH2 IHE IX1 J0M J5H K48 KBYEO L7B LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N4W N9A NF~ O66 O9- OIG OK1 OVD P2P P2W P2X P2Z P4B P4D PALCI Q.N Q11 QB0 R.K RIWAO RJQFR ROL RX1 SAMSI SUPJJ TEORI UB1 V8K V9Y VH1 W8V W99 WBKPD WHWMO WIH WIJ WIK WIN WOHZO WOW WQJ WRC WUP WVDHM WXI WXSBR X7M XG1 YFH YOC YUY ZGI ZXP ZZTAW ~IA ~WT AAVGM ABHUG ABMYL ABWRO ACXME ADAWD ADDAD AFVGU AGJLS AQVPL IQODW ZA5 CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
ID | FETCH-LOGICAL-c5161-32c5815ba51fb65c3e34142f94cfec4d4d6cdcdcbb7592e2d24066c1bcd60abd3 |
IEDL.DBID | DR2 |
ISSN | 0007-1048 |
IngestDate | Sat Aug 17 00:11:59 EDT 2024 Fri Aug 23 03:40:50 EDT 2024 Thu May 23 23:51:34 EDT 2024 Wed Mar 20 09:21:23 EDT 2024 Sat Aug 24 00:54:00 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Keywords | Human Nonsense mutation Genetic variant Metabolism toxicity relation Oral administration Anticoagulant Hemorrhage Chemotherapy Factor IX Treatment Risk factor Complication Biosynthesis precursor Coagulation factor |
Language | English |
License | CC BY 4.0 |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c5161-32c5815ba51fb65c3e34142f94cfec4d4d6cdcdcbb7592e2d24066c1bcd60abd3 |
Notes | ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 |
OpenAccessLink | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2141.1997.2213036.x |
PMID | 9233593 |
PQID | 79156990 |
PQPubID | 23479 |
PageCount | 5 |
ParticipantIDs | proquest_miscellaneous_79156990 crossref_primary_10_1046_j_1365_2141_1997_2213036_x pubmed_primary_9233593 pascalfrancis_primary_2750554 wiley_primary_10_1046_j_1365_2141_1997_2213036_x_BJH221 |
PublicationCentury | 1900 |
PublicationDate | July 1997 |
PublicationDateYYYYMMDD | 1997-07-01 |
PublicationDate_xml | – month: 07 year: 1997 text: July 1997 |
PublicationDecade | 1990 |
PublicationPlace | Oxford, UK |
PublicationPlace_xml | – name: Oxford, UK – name: Oxford – name: England |
PublicationTitle | British journal of haematology |
PublicationTitleAlternate | Br J Haematol |
PublicationYear | 1997 |
Publisher | Blackwell Science Ltd Blackwell |
Publisher_xml | – name: Blackwell Science Ltd – name: Blackwell |
References | 10847705 - Br J Haematol. 2000 Mar;108(3):663 9375777 - Br J Haematol. 1997 Nov;99(2):467-8 |
References_xml | |
SSID | ssj0013051 |
Score | 1.869945 |
Snippet | Bleeding complications are the most common and unwanted side‐effect of oral anticoagulant therapy. We report three patients in whom mutations in the factor IX... Bleeding complications are the most common and unwanted side-effect of oral anticoagulant therapy. We report three patients in whom mutations in the factor IX... |
SourceID | proquest crossref pubmed pascalfrancis wiley |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 240 |
SubjectTerms | Administration, Oral Adult Aged Anticoagulants - adverse effects Biological and medical sciences bleeding Blood. Blood coagulation. Reticuloendothelial system Exons - genetics factor IX Factor IX - genetics Hemorrhage - chemically induced Hemorrhage - genetics Humans Medical sciences Mutation mutations oral anticoagulant therapy Peptide Fragments - genetics Pharmacology. Drug treatments propeptide |
Title | Missense mutations at ALA‐10 in the factor IX propeptide: an insignificant variant in normal life but a decisive cause of bleeding during oral anticoagulant therapy |
URI | https://onlinelibrary.wiley.com/doi/abs/10.1046%2Fj.1365-2141.1997.2213036.x https://www.ncbi.nlm.nih.gov/pubmed/9233593 https://search.proquest.com/docview/79156990 |
Volume | 98 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9NAEF6hHiokBOVREUphDlwd-bFrx72FiipUTQ8VlXJb7RNVpE5E7Ao48RP4Ff1h_SWd8dqpAlyoOEVWtOu157Hfema-YewdZVNw7l2U5XEW8ZFCmzPORIkfxVoba0IV__Q0n5zz45mYdeXRVAsT-CHWH9zIMlp_TQaudOhCErfstn2GVsITKrkrhmna-uMhIUpi1iOEdJbehRRi0bXPK9D38FHPQMrvkr3-nGpjt3q0VCt8cT50vPgbJN1EuO0WdfSEXfYPFzJTvgybWg_Nj994H__X0--wxx2WhXFQvqfsgauese1pF61_zq6nFOyvVg4umxDxX4GqYXwyvvn5K4nhogKEnxBa_sDHGSwpMoA-zLoDUBX-T9kllMuE4ocrPNXTL46qCGjPYX7hHeimBgW2bRV05cCoBu-38KDnYV-GUIgJxESAk-JSF-pzM6eZQu3Z9xfs_OjDp8NJ1PWFiIxI6HNZasQoEVqJxOtcmMzhVsxTX3LjneGW2xyVzBqtC1GmLrWEWnKToOrlsdI222Vb1aJyLxl4kWniKsVjXIFQ0qiy0NZRo0J0ZL7IBizr5S-Xgf5DtmF7TiVuJAJJIpAkAtmJQH4bsP0NVVkPJTJ9xG8D9rZXHYnWTCEaVblFs5JFiedpBAgDths0aj0UgXgmSlxQ0arFP6xGvj-e4MWre4_cYw8DaS8lKb9mW_XXxu0jFKv1m9bEbgEAUSbH |
link.rule.ids | 315,786,790,1382,27957,27958,46329,46753 |
linkProvider | Wiley-Blackwell |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NbtQwELaqVgIkVH4rtlA6B65Z8mMnG24LotqWTQ-olfZm2Y5dVSzZFZtUwKmPwFPwYDwJM3Gy1QIXEKcoiuw48Tfjz54_xl6QNwXnzgZJGiYBHymUOWNNELlRqLUpjY_iL07TyTk_mYnZFiv6WBifH2J94EaS0eprEnA6kH7ZmSW9lLcuWhGPKOYuG8Zxq5CHSCl3UP5Fu8N6H98YFULRFdDLUPvwUZ-DlN-4e_3e18Z6dXepVvjrnK958SdSuslx20Xq6B6r-s_zvikfhk2th-brL5kf_9v332e7HZ2FscffA7Zlq4fsVtEZ7B-x7wXZ-6uVhY-NN_qvQNUwno5_XH-LQrisABko-Ko_cDyDJRkHUI2V9hWoCp-Tgwm5MyEC4Ao39nTFVhVx7TnML50F3dSgoGyrBV1ZMKrB9y0c6LlfmsHHYgIlI8BOcagLddHMqScffvblMTs_env2ZhJ0pSECIyI6MYuNGEVCKxE5nQqTWFyNeexybpw1vORlijgrjdaZyGMbl0RcUhMh-tJQ6TLZY9vVorJPGDiRaEpXiju5DNmkUXmmS0u1ClGXuSwZsKQHgFz6DCCytdxzinKjKZA0BZKmQHZTID8P2MEGVtZNKZ8-UrgBO-yxI1GgyUqjKrtoVjLLcUuNHGHA9jyk1k2RiycixwFlLS7-YjTy9ckEb_b_ueUhuz05K6Zyenz67im743P4ks_yM7Zdf2rsATKzWj9v5e0nehAq6Q |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9NAEF6hIlVIiHdFCqVz4Orgx64dcwuUKC1NhRCVclvts6pInYjYVeHET-BX8MP4Jcx4nVQBLiBOlmXNeu157Lc7L8aeUzQF595FWR5nER8o1DnjTJT4Qay1sSZk8U9O8vEpP5qKaZceTbkwoT7E-sCNNKO116TgC-tfdF7JoORthFbCE0q5K_pp2trjPiLKmzzPUpLxg_fptU8hFl3_vAKNDx-sSpDy62iv38faWK5uL9QS_5wPLS_-hEk3IW67Ro3usovV14XQlI_9ptZ98-WXwo__6_PvsTsdmIVhkL777IarHrDtSeeuf8i-T8jbXy0dXDTB5b8EVcPwePjj67ckhvMKEH9C6PkDh1NYkGsAjZh1L0FV-JzCSyiYCfkPl7itpytSVYS0ZzA79w50U4MC2_YKunRgVIPvm3vQs7AwQ8jEBCpFgIPiVOfqrJnRSCH57PMjdjp68-H1OOoaQ0RGJHRelhoxSIRWIvE6FyZzuBbz1JfceGe45TZHKbNG60KUqUstwZbcJCh7eay0zXbYVjWv3GMGXmSaipXiPq5ALGlUWWjrqFMhWjJfZD2WrfgvF6H-h2z99pxy3IgFklggiQWyY4G86rG9DVFZk1I1fQRwPba_Eh2J6kw-GlW5ebOURYkbakQIPbYTJGpNikg8EyVOqGjF4i9mI18djfFm958p99n2u4ORPD48efuE3QoFfClg-Snbqj81bg9hWa2ftdr2E808KZg |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Missense+mutations+at+ALA-10+in+the+factor+IX+propeptide%3A+an+insignificant+variant+in+normal+life+but+a+decisive+cause+of+bleeding+during+oral+anticoagulant+therapy&rft.jtitle=British+journal+of+haematology&rft.au=Oldenburg%2C+J&rft.au=Quenzel%2C+E+M&rft.au=Harbrecht%2C+U&rft.au=Fregin%2C+A&rft.date=1997-07-01&rft.issn=0007-1048&rft.volume=98&rft.issue=1&rft.spage=240&rft.epage=244&rft_id=info:doi/10.1046%2Fj.1365-2141.1997.2213036.x&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0007-1048&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0007-1048&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0007-1048&client=summon |