Separation of five compounds from leaves of Andrographis paniculata (Burm. f.) Nees by off-line two-dimensional high-speed counter-current chromatography combined with gradient and recycling elution
An off‐line two‐dimensional high‐speed counter‐current chromatography method combined with gradient and recycling elution mode was established to isolate terpenoids and flavones from the leaves of Andrographis paniculata (Burm. f.) Nees. By using the solvent systems composed of n‐hexane/ethyl acetat...
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| Published in | Journal of separation science Vol. 38; no. 9; pp. 1476 - 1483 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Germany
Blackwell Publishing Ltd
01.05.2015
Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
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| Abstract | An off‐line two‐dimensional high‐speed counter‐current chromatography method combined with gradient and recycling elution mode was established to isolate terpenoids and flavones from the leaves of Andrographis paniculata (Burm. f.) Nees. By using the solvent systems composed of n‐hexane/ethyl acetate/methanol/water with different volume ratios, five compounds including roseooside, 5,4′‐dihydroxyflavonoid‐7‐O‐β‐d‐pyranglucuronatebutylester, 7,8‐dimethoxy‐2′‐hydroxy‐5‐O‐β‐d‐glucopyranosyloxyflavon, 14‐deoxyandrographiside, and andrographolide were successfully isolated. Purities of these isolated compounds were all over 95% as determined by high‐performance liquid chromatography. Their structures were identified by UV, mass spectrometry, and 1H NMR spectroscopy. It has been demonstrated that the combination of off‐line two‐dimensional high‐speed counter‐current chromatography with different elution modes is an efficient technique to isolate compounds from complex natural product extracts. |
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| AbstractList | An off‐line two‐dimensional high‐speed counter‐current chromatography method combined with gradient and recycling elution mode was established to isolate terpenoids and flavones from the leaves of
Andrographis paniculata
(Burm. f.) Nees. By using the solvent systems composed of
n
‐hexane/ethyl acetate/methanol/water with different volume ratios, five compounds including roseooside, 5,4′‐dihydroxyflavonoid‐7‐
O
‐β‐
d
‐pyranglucuronatebutylester, 7,8‐dimethoxy‐2′‐hydroxy‐5‐
O
‐β‐
d
‐glucopyranosyloxyflavon, 14‐deoxyandrographiside, and andrographolide were successfully isolated. Purities of these isolated compounds were all over 95% as determined by high‐performance liquid chromatography. Their structures were identified by UV, mass spectrometry, and
1
H NMR spectroscopy. It has been demonstrated that the combination of off‐line two‐dimensional high‐speed counter‐current chromatography with different elution modes is an efficient technique to isolate compounds from complex natural product extracts. An off-line two-dimensional high-speed counter-current chromatography method combined with gradient and recycling elution mode was established to isolate terpenoids and flavones from the leaves of Andrographis paniculata (Burm. f.) Nees. By using the solvent systems composed of n-hexane/ethyl acetate/methanol/water with different volume ratios, five compounds including roseooside, 5,4'-dihydroxyflavonoid-7-O- beta -d-pyranglucuronatebutylester , 7,8-dimethoxy-2'-hydroxy-5-O- beta -d-glucopyranosyloxyflavon, 14-deoxyandrographiside, and andrographolide were successfully isolated. Purities of these isolated compounds were all over 95% as determined by high-performance liquid chromatography. Their structures were identified by UV, mass spectrometry, and super(1)H NMR spectroscopy. It has been demonstrated that the combination of off-line two-dimensional high-speed counter-current chromatography with different elution modes is an efficient technique to isolate compounds from complex natural product extracts. An off-line two-dimensional high-speed counter-current chromatography method combined with gradient and recycling elution mode was established to isolate terpenoids and flavones from the leaves of Andrographis paniculata (Burm. f.) Nees. By using the solvent systems composed of n-hexane/ethyl acetate/methanol/water with different volume ratios, five compounds including roseooside, 5,4'-dihydroxyflavonoid-7-O-β-d-pyranglucuronatebutylester, 7,8-dimethoxy-2'-hydroxy-5-O-β-d-glucopyranosyloxyflavon, 14-deoxyandrographiside, and andrographolide were successfully isolated. Purities of these isolated compounds were all over 95% as determined by high-performance liquid chromatography. Their structures were identified by UV, mass spectrometry, and (1) H NMR spectroscopy. It has been demonstrated that the combination of off-line two-dimensional high-speed counter-current chromatography with different elution modes is an efficient technique to isolate compounds from complex natural product extracts. An off-line two-dimensional high-speed counter-current chromatography method combined with gradient and recycling elution mode was established to isolate terpenoids and flavones from the leaves of Andrographis paniculata (Burm. f.) Nees. By using the solvent systems composed of n-hexane/ethyl acetate/methanol/water with different volume ratios, five compounds including roseooside, 5,4'-dihydroxyflavonoid-7-O-[beta]-d-pyranglucuronatebutylester, 7,8-dimethoxy-2'-hydroxy-5-O-[beta]-d-glucopyranosyloxyflavon, 14-deoxyandrographiside, and andrographolide were successfully isolated. Purities of these isolated compounds were all over 95% as determined by high-performance liquid chromatography. Their structures were identified by UV, mass spectrometry, and 1H NMR spectroscopy. It has been demonstrated that the combination of off-line two-dimensional high-speed counter-current chromatography with different elution modes is an efficient technique to isolate compounds from complex natural product extracts. An off‐line two‐dimensional high‐speed counter‐current chromatography method combined with gradient and recycling elution mode was established to isolate terpenoids and flavones from the leaves of Andrographis paniculata (Burm. f.) Nees. By using the solvent systems composed of n‐hexane/ethyl acetate/methanol/water with different volume ratios, five compounds including roseooside, 5,4′‐dihydroxyflavonoid‐7‐O‐β‐d‐pyranglucuronatebutylester, 7,8‐dimethoxy‐2′‐hydroxy‐5‐O‐β‐d‐glucopyranosyloxyflavon, 14‐deoxyandrographiside, and andrographolide were successfully isolated. Purities of these isolated compounds were all over 95% as determined by high‐performance liquid chromatography. Their structures were identified by UV, mass spectrometry, and 1H NMR spectroscopy. It has been demonstrated that the combination of off‐line two‐dimensional high‐speed counter‐current chromatography with different elution modes is an efficient technique to isolate compounds from complex natural product extracts. |
| Author | Yu, Jingang Chen, Xiaoqing Jiang, Shujing Zeng, Hualiang Zhang, Li Liu, Qi |
| Author_xml | – sequence: 1 givenname: Li surname: Zhang fullname: Zhang, Li organization: College of Chemistry and Chemical Engineering, Central South University, Changsha, China – sequence: 2 givenname: Qi surname: Liu fullname: Liu, Qi organization: College of Chemistry and Chemical Engineering, Central South University, Changsha, China – sequence: 3 givenname: Jingang surname: Yu fullname: Yu, Jingang organization: College of Chemistry and Chemical Engineering, Central South University, Changsha, China – sequence: 4 givenname: Hualiang surname: Zeng fullname: Zeng, Hualiang organization: College of Chemistry and Chemical Engineering, Central South University, Changsha, China – sequence: 5 givenname: Shujing surname: Jiang fullname: Jiang, Shujing organization: College of Chemistry and Chemical Engineering, Central South University, Changsha, China – sequence: 6 givenname: Xiaoqing surname: Chen fullname: Chen, Xiaoqing email: xqchen@csu.edu.cn organization: College of Chemistry and Chemical Engineering, Central South University, Changsha, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25675944$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.chroma.2013.02.079 10.1016/j.chroma.2006.07.044 10.1093/chromsci/47.5.337 10.1002/jssc.201400293 10.1016/j.phytochem.2004.05.008 10.1158/1535-7163.MCT-08-0071 10.1021/ac100121j 10.1016/j.fitote.2003.12.018 10.1016/j.chroma.2014.08.087 10.1081/JLC-200063550 10.1002/jssc.201300653 10.1055/s-2004-818938 10.1016/j.chroma.2006.02.081 10.1016/j.jpba.2012.05.037 10.1016/j.tips.2005.09.006 10.1002/jssc.200900033 10.1016/S0021-9673(02)01831-9 10.1016/j.chroma.2007.02.099 10.1002/ptr.1765 10.1002/1439-2054(20010301)286:3<161::AID-MAME161>3.0.CO;2-Z 10.1016/j.jchromb.2014.01.028 10.1016/j.foodchem.2014.08.120 10.1016/j.chroma.2011.12.036 10.1002/jssc.201400168 10.1016/j.talanta.2012.04.010 10.1080/14786410410001709197 10.1016/j.chroma.2013.07.043 10.1002/jssc.201300896 10.1002/jssc.201400051 10.1016/j.lfs.2010.12.019 10.1126/science.167.3916.281 10.1016/j.jff.2014.04.023 10.1002/jssc.201400812 10.1016/j.intimp.2008.12.002 10.1016/j.chroma.2007.01.141 10.1016/j.chroma.2011.06.015 10.1080/08923970600626007 10.1016/j.chroma.2014.07.040 |
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| Copyright | 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
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| Keywords | Recycling elution Andrographis paniculata (Burm. f.) Nees Gradient elution High-speed counter-current chromatography |
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| References | Sheeja, K., Shihab, P., Kuttan, G., Immunopharm. Immunot. 2006, 28, 129-140. He, S., Lu, Y., Jiang, L., Wu, B., Zhang, F., Pan, Y., J. Sep. Sci. 2009, 32, 2339-2345. Abu-Ghefreh, A. A. A., Canatan, H., Ezeamuzie, C. I., Int. Immunopharmacol. 2009, 9, 313-318. Wei, J., Zhang, T. Y., Ito, Y., J. Liq. Chromatogr. Relat. Technol. 2005, 28, 1903-1911. Lu, Y., Sun, C., Liu, R., Pan, Y., J. Chromatogr. A 2007, 1146, 125-130. Du, Q., Jerz, G., Winterhalter, P., J. Chromatogr. A 2003, 984, 147-151. Ito, Y., Bowman, R. L., Science 1970, 167, 281-283. Chturvedi, G., Tomar, G., Tiwari, S., Singh, K., Anc. Sci. Life 1983, 2, 208. Ooi, J. P., Kuroyanagi, M., Sulaiman, S. F., Muhammad, T. S. T., Tan, M. L., Life Sci. 2011, 88, 447-454. Chu, C., Zhang, S., Tong, S., Li, X., Yan, J., J. Sep. Sci. 2013, 36, 3958-3964. Tong, S., Guan, Y.-X., Yan, J., Zheng, B., Zhao, L., J. Chromatogr. A 2011, 1218, 5434-5440. Jiang, W.-Y., Trends Pharmacol. Sci. 2005, 26, 558-563. Ma, S., Liang, Q., Jiang, Z., Wang, Y., Luo, G., Talanta 2012, 97, 150-156. Khatune, N. A., Ekramul Islam, M., Ekramul Haque, M., Khondkar, P., Mukhlesur Rahman, M., Fitoterapia 2004, 75, 228-230. Zhou, J., Lu, G.-D., Ong, C.-S., Ong, C.-N., Shen, H.-M., Mol. Cancer Ther. 2008, 7, 2170-2180. Liu, Q., Shi, S., Liu, L., Yang, H., Su, W., Chen, X., J. Chromatogr. A 2013, 1304, 183-193. Niranjan Reddy, V. L., Malla Reddy, S., Ravikanth, V., Krishnaiah, P., Venkateshwar Goud, T., Rao, T. P., Siva Ram, T., Gonnade Rajesh, G., Bhadbhade, Mohan., Venkateswarlu, Y., Nat. Prod. Res. 2005, 19, 223-230. Ito, Y., J. Chromatogr. A 2005, 1065, 145-168. Chen, M., Liu, L., Chen, X., J. Sep. Sci. 2014, 37, 1546-1551. Zhang, P., Sun, G., Tang, K., Yang, W., Sui, G., Zhou, C. J. Sep. Sci. 2014, 37, 3443-3450. Liu, Q., Xiao, J., Yu, J., Xie, Y., Chen, X., Yang, H., J. Chromatogr. A 2014, 1363, 236-241 Koteswara Rao, Y., Vimalamma, G., Venkata Rao, C., Tzeng, Y.-M., Phytochemistry 2004, 65, 2317-2321. Lu, Y., Sun, C., Wang, Y., Pan, Y., J. Chromatogr. A 2007, 1151, 31-36. Liu, Q., Zhou, J., Yu, J., Xie, Y., Jiang, X., Yang, H., Chen, X., J. Chromatogr. A 2014, 1364, 204-213. Yang, M., Wang, J., Kong, L., J. Pharmaceut. Biomed. 2012, 70, 87-93. Ernst, E., Planta Med. 2004, 70, 293-298. Liu, Q., Zeng, H., Jiang, S., Zhang, L., Yang, F., Chen, X., Yang, H., Food Chem. 2014, doi: 10.1016/j.foodchem.2014.08.120. Ren, D. B., Qin, Y. H., Yun, Y. H., Lu, H. M., Chen, X. Q., Liang, Y. Z., J. Sep. Sci. 2014, 37, 2118-2125. Wiart, C., Kumar, K., Yusof, M., Hamimah, H., Fauzi, Z. M., Sulaiman, M., Phytother. Res. 2005, 19, 1069-1070. Wang, J., Yang, W., Wang, G., Tang, P., Sai, Y., J. Chromatogr. B 2014, 951, 78-88. Yang, E.-J., Song, K.-S., J. Funct. Foods 2014, 9, 162-172. Liang, J., Meng, J., Guo, M., Yang, Z., Wu, S., J. Chromatogr. A 2013, 1288, 35-39. Lu, Y., Hu, R., Pan, Y., Anal. Chem. 2010, 82, 3081-3085. Ruan, C., Xiao, X. H., Li, G. K., J. Sep. Sci. 2014, 37, 1364-1369. Wu, D., Cao, X., Wu, S., J. Chromatogr. A 2012, 1223, 53-63. Han, Q. B., Song, J. Z., Qiao, C. F., Wong, L., Xu, H. X., J. Chromatogr. A 2006, 1127, 298-301. Su, W., Liu, Q., Yang, Q., Yu, J., Chen, X., J. Sep. Sci. 2013, 36, 3338-3344. Wei, Y., Ito, Y., J. Chromatogr. A 2006, 1115, 112-117. Li, H.-B., Chen, F., J. Chromatogr. Sci. 2009, 47, 337-340. 2004; 65 2009; 47 2012; 1223 1970; 167 1983; 2 2007; 1146 2008; 7 2006; 1127 2014; 1364 2014; 1363 2005; 26 2005; 28 2012; 97 2014; 951 2010; 82 2012; 70 2004; 75 2005; 19 2013; 36 2007; 1151 2009; 32 2004; 70 2013; 1304 2013; 1288 2006; 28 2006; 1115 2014; 37 2005; 1065 2009; 9 2011; 88 2011; 1218 2014 2014; 9 2003; 984 e_1_2_8_28_1 e_1_2_8_29_1 e_1_2_8_25_1 e_1_2_8_26_1 e_1_2_8_27_1 e_1_2_8_3_1 e_1_2_8_2_1 e_1_2_8_5_1 e_1_2_8_4_1 e_1_2_8_7_1 e_1_2_8_6_1 e_1_2_8_9_1 e_1_2_8_8_1 e_1_2_8_20_1 e_1_2_8_21_1 e_1_2_8_22_1 e_1_2_8_23_1 e_1_2_8_40_1 e_1_2_8_17_1 e_1_2_8_18_1 e_1_2_8_39_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_36_1 e_1_2_8_14_1 e_1_2_8_35_1 e_1_2_8_15_1 e_1_2_8_38_1 e_1_2_8_16_1 e_1_2_8_37_1 Chturvedi G. (e_1_2_8_24_1) 1983; 2 e_1_2_8_32_1 e_1_2_8_10_1 e_1_2_8_31_1 e_1_2_8_11_1 e_1_2_8_34_1 e_1_2_8_12_1 e_1_2_8_33_1 e_1_2_8_30_1 |
| References_xml | – volume: 1363 start-page: 236 year: 2014 end-page: 241 publication-title: J. Chromatogr. A – volume: 1304 start-page: 183 year: 2013 end-page: 193 publication-title: J. Chromatogr. A – volume: 9 start-page: 313 year: 2009 end-page: 318 publication-title: Int. Immunopharmacol. – volume: 1065 start-page: 145 year: 2005 end-page: 168 publication-title: J. Chromatogr. A – volume: 9 start-page: 162 year: 2014 end-page: 172 publication-title: J. Funct. Foods – volume: 36 start-page: 3338 year: 2013 end-page: 3344 publication-title: J. Sep. Sci. – volume: 82 start-page: 3081 year: 2010 end-page: 3085 publication-title: Anal. Chem. – volume: 32 start-page: 2339 year: 2009 end-page: 2345 publication-title: J. Sep. Sci – volume: 2 start-page: 208 year: 1983 publication-title: Anc. Sci. Life – volume: 28 start-page: 129 year: 2006 end-page: 140 publication-title: Immunopharm. Immunot. – volume: 1115 start-page: 112 year: 2006 end-page: 117 publication-title: J. Chromatogr. A – volume: 97 start-page: 150 year: 2012 end-page: 156 publication-title: Talanta – volume: 1288 start-page: 35 year: 2013 end-page: 39 publication-title: J. Chromatogr. A – volume: 167 start-page: 281 year: 1970 end-page: 283 publication-title: Science – volume: 65 start-page: 2317 year: 2004 end-page: 2321 publication-title: Phytochemistry – volume: 1218 start-page: 5434 year: 2011 end-page: 5440 publication-title: J. Chromatogr. A – volume: 37 start-page: 3443 year: 2014 end-page: 3450 publication-title: J. Sep. Sci. – volume: 19 start-page: 223 year: 2005 end-page: 230 publication-title: Nat. Prod. Res. – volume: 37 start-page: 1364 year: 2014 end-page: 1369 publication-title: J. Sep. Sci. – volume: 19 start-page: 1069 year: 2005 end-page: 1070 publication-title: Phytother. Res. – volume: 37 start-page: 2118 year: 2014 end-page: 2125 publication-title: J. Sep. Sci. – volume: 37 start-page: 1546 year: 2014 end-page: 1551 publication-title: J. Sep. Sci. – volume: 984 start-page: 147 year: 2003 end-page: 151 publication-title: J. Chromatogr. A – volume: 1151 start-page: 31 year: 2007 end-page: 36 publication-title: J. Chromatogr. A – volume: 1127 start-page: 298 year: 2006 end-page: 301 publication-title: J. Chromatogr. A – volume: 26 start-page: 558 year: 2005 end-page: 563 publication-title: Trends Pharmacol. Sci. – volume: 1146 start-page: 125 year: 2007 end-page: 130 publication-title: J. Chromatogr. A – volume: 70 start-page: 87 year: 2012 end-page: 93 publication-title: J. Pharmaceut. Biomed. – volume: 75 start-page: 228 year: 2004 end-page: 230 publication-title: Fitoterapia – volume: 7 start-page: 2170 year: 2008 end-page: 2180 publication-title: Mol. Cancer Ther. – volume: 70 start-page: 293 year: 2004 end-page: 298 publication-title: Planta Med. – volume: 47 start-page: 337 year: 2009 end-page: 340 publication-title: J. Chromatogr. Sci. – volume: 1364 start-page: 204 year: 2014 end-page: 213 publication-title: J. Chromatogr. A – volume: 951 start-page: 78 year: 2014 end-page: 88 publication-title: J. Chromatogr. B – volume: 28 start-page: 1903 year: 2005 end-page: 1911 publication-title: J. Liq. Chromatogr. Relat. Technol. – year: 2014 publication-title: Food Chem. – volume: 1223 start-page: 53 year: 2012 end-page: 63 publication-title: J. Chromatogr. A – volume: 36 start-page: 3958 year: 2013 end-page: 3964 publication-title: J. Sep. Sci. – volume: 88 start-page: 447 year: 2011 end-page: 454 publication-title: Life Sci. – ident: e_1_2_8_5_1 doi: 10.1016/j.chroma.2013.02.079 – ident: e_1_2_8_16_1 doi: 10.1016/j.chroma.2006.07.044 – ident: e_1_2_8_3_1 doi: 10.1093/chromsci/47.5.337 – ident: e_1_2_8_15_1 doi: 10.1002/jssc.201400293 – ident: e_1_2_8_26_1 doi: 10.1016/j.phytochem.2004.05.008 – ident: e_1_2_8_29_1 doi: 10.1158/1535-7163.MCT-08-0071 – ident: e_1_2_8_10_1 doi: 10.1021/ac100121j – ident: e_1_2_8_28_1 doi: 10.1016/j.fitote.2003.12.018 – volume: 2 start-page: 208 year: 1983 ident: e_1_2_8_24_1 publication-title: Anc. Sci. Life contributor: fullname: Chturvedi G. – ident: e_1_2_8_11_1 doi: 10.1016/j.chroma.2014.08.087 – ident: e_1_2_8_38_1 doi: 10.1081/JLC-200063550 – ident: e_1_2_8_6_1 doi: 10.1002/jssc.201300653 – ident: e_1_2_8_22_1 doi: 10.1055/s-2004-818938 – ident: e_1_2_8_39_1 doi: 10.1016/j.chroma.2006.02.081 – ident: e_1_2_8_33_1 doi: 10.1016/j.jpba.2012.05.037 – ident: e_1_2_8_25_1 doi: 10.1016/j.tips.2005.09.006 – ident: e_1_2_8_14_1 doi: 10.1002/jssc.200900033 – ident: e_1_2_8_37_1 doi: 10.1016/S0021-9673(02)01831-9 – ident: e_1_2_8_9_1 doi: 10.1016/j.chroma.2007.02.099 – ident: e_1_2_8_27_1 doi: 10.1002/ptr.1765 – ident: e_1_2_8_40_1 doi: 10.1002/1439-2054(20010301)286:3<161::AID-MAME161>3.0.CO;2-Z – ident: e_1_2_8_23_1 doi: 10.1016/j.jchromb.2014.01.028 – ident: e_1_2_8_12_1 doi: 10.1016/j.foodchem.2014.08.120 – ident: e_1_2_8_36_1 doi: 10.1016/j.chroma.2011.12.036 – ident: e_1_2_8_7_1 doi: 10.1002/jssc.201400168 – ident: e_1_2_8_21_1 doi: 10.1016/j.talanta.2012.04.010 – ident: e_1_2_8_34_1 doi: 10.1080/14786410410001709197 – ident: e_1_2_8_20_1 doi: 10.1016/j.chroma.2013.07.043 – ident: e_1_2_8_13_1 doi: 10.1002/jssc.201300896 – ident: e_1_2_8_4_1 doi: 10.1002/jssc.201400051 – ident: e_1_2_8_35_1 doi: 10.1016/j.lfs.2010.12.019 – ident: e_1_2_8_2_1 doi: 10.1126/science.167.3916.281 – ident: e_1_2_8_32_1 doi: 10.1016/j.jff.2014.04.023 – ident: e_1_2_8_18_1 doi: 10.1002/jssc.201400812 – ident: e_1_2_8_31_1 doi: 10.1016/j.intimp.2008.12.002 – ident: e_1_2_8_8_1 doi: 10.1016/j.chroma.2007.01.141 – ident: e_1_2_8_17_1 doi: 10.1016/j.chroma.2011.06.015 – ident: e_1_2_8_30_1 doi: 10.1080/08923970600626007 – ident: e_1_2_8_19_1 doi: 10.1016/j.chroma.2014.07.040 |
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| SubjectTerms | Andrographis - chemistry Andrographis paniculata (Burm. f.) Nees Chromatography Chromatography, High Pressure Liquid Diterpenes - chemistry Diterpenes - isolation & purification Elution Flavones - chemistry Flavones - isolation & purification Flavonoids - chemistry Flavonoids - isolation & purification Flowers & plants Glucosides - chemistry Glucosides - isolation & purification Glucuronates - chemistry Glucuronates - isolation & purification Gradient elution High speed High-speed counter-current chromatography Metabolites Methyl alcohol Molecular Conformation Natural products NMR spectroscopy Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Leaves - chemistry Recycling Recycling elution Separation Two dimensional |
| Title | Separation of five compounds from leaves of Andrographis paniculata (Burm. f.) Nees by off-line two-dimensional high-speed counter-current chromatography combined with gradient and recycling elution |
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