The green tea polyphenol, epigallocatechin‐3‐gallate, inhibits hepatitis C virus entry

• Published in: Hepatology (Baltimore, Md.) Vol. 54; no. 6; pp. 1947 - 1955
• Main Authors: Ciesek, Sandra, von Hahn, Thomas, Colpitts, Che C., Schang, Luis M., Friesland, Martina, Steinmann, Jörg, Manns, Michael P., Ott, Michael, Wedemeyer, Heiner, Meuleman, Philip, Pietschmann, Thomas, Steinmann, Eike
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.12.2011; Wiley; Wiley Subscription Services, Inc
• Subjects: Biological and medical sciences; Catechin - analogs & derivatives; Catechin - pharmacology; Cell Line, Tumor; Cells, Cultured; Gastroenterology. Liver. Pancreas. Abdomen; Hepacivirus - drug effects; Hepacivirus - physiology; Hepatitis; Hepatitis C; Hepatitis C - prevention & control; Hepatitis C virus; Hepatology; Humans; Liver cirrhosis; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; Tea; Tea - chemistry; Transplants & implants; Virus Attachment - drug effects; Virus Internalization - drug effects; Virus; Polyphenol; Gastroenterology; Phenols; Flaviviridae; Hepatitis C virus; Hepacivirus; Green tea

Hepatitis C virus (HCV) is a major cause of liver cirrhosis and hepatocellular carcinoma. Current antiviral therapy fails to clear infection in a substantial proportion of cases. Drug development is focused on nonstructural proteins required for RNA replication. Individuals undergoing orthotopic liv...