Lymphatic Drainage-Promoting Effects by Engraftment of Artificial Lymphatic Vascular Tissue Based on Human Adipose Tissue-Derived Mesenchymal Stromal Cells in Mice

• Published in: Journal of tissue engineering and regenerative medicine Vol. 2023; pp. 1 - 15
• Main Authors: Asano, Yoshiya, Shimoda, Hiroshi, Okano, Daisuke, Matsusaki, Michiya, Akashi, Mitsuru
• Format: Journal Article
• Language: English
• Published: England Hindawi 2023; John Wiley & Sons, Inc
• Subjects: Adipose tissue; Adipose Tissue - cytology; Angiogenesis; Animals; Blood vessels; Body fat; Construction; Dextran; Dextrans; Endothelial cells; Endothelial Cells - cytology; Endothelial Cells - metabolism; Engraftment; Extracellular matrix; Fibroblast growth factor 2; Fibroblasts; Humans; Ischemia; Lymph nodes; Lymphangiogenesis; Lymphatic drainage; Lymphatic system; Lymphatic Vessels; Lymphedema; Mesenchymal Stem Cell Transplantation; Mesenchymal stem cells; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - metabolism; Mice; Microscopy; Network formation; Regeneration (physiology); Regenerative medicine; Software; Stromal cells; Therapeutic applications; Tissue engineering; Tissue Engineering - methods; Transplantation; Transplants & implants; Vascular endothelial growth factor; Vascular tissue; Japan; Germany; Fiji

Regenerative medicine using lymphatic vascular engineering is a promising approach for treating lymphedema. However, its development lags behind that of artificial blood vascular tissue for ischemic diseases. In this study, we constructed artificial 3D lymphatic vascular tissue, termed ASCLT, by co-...