Control of appetite and energy intake by SCFA: what are the potential underlying mechanisms?

• Published in: Proceedings of the Nutrition Society Vol. 74; no. 3; pp. 328 - 336
• Main Authors: Chambers, Edward S., Morrison, Douglas J., Frost, Gary
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.08.2015
• Subjects: acetates; adipocytes; Adipose tissue; Animal models; Animals; Appetite; Appetite Regulation - physiology; biochemical pathways; Colon - metabolism; Conference on ‘Carbohydrates in health: friends or foes’; Diet; Dietary fiber; digestive system; Energy; energy intake; Energy Intake - physiology; epithelium; Fatty Acids, Volatile - biosynthesis; Fatty Acids, Volatile - metabolism; Feeding behavior; Fermentation; free fatty acids; G-protein coupled receptors; Gastrointestinal Hormones - metabolism; glucagon-like peptide 1; glucose; Glucose - biosynthesis; homeostasis; Homeostasis - physiology; Hormones; Human subjects; Humans; Hypothalamus; leptin; Liver - metabolism; Nervous system; Obesity; Physiology; propionic acid; Proteins; Public health; ruminants; Symposium 4: Whole grains, dietary fibre and grain-derived phytochemicals; tyrosine; Weight control; Whooping cough; Appetite; Obesity; Gut hormone; SCFA; Colonic fermentation; GLP glucagon-like peptide; PYY peptide tyrosine tyrosine; GI gastrointestinal; POMC pro-opiomelanocortin; ARC arcuate nucleus; FFAR free fatty acid receptor

In recent years, there has been a renewed interest in the role of dietary fibre in obesity management. Much of this interest stems from animal and human studies which suggest that an increased intake of fermentable fibre can suppress appetite and improve weight management. A growing number of report...