Use of ultra-high pressure liquid chromatography coupled to high resolution mass spectrometry for fast screening in high throughput doping control - Musenga, Alessandro; Cowan, David A. (Journal of Chromatography A, 2013)
Keywords: Analysis; Analytical chemistry; beta-adrenergic antagonists; Bioanalysis; Biological and medical sciences; Chromatography; Chromatography, High Pressure Liquid - methods; Cost analysis; dissociation; Diuretics; Doping control; Doping in Sports; enzymatic hydrolysis; Fast screening; General pharmacology; glucocorticoids; High resolution; High resolution mass spectrometry; High-Throughput Screening Assays - methods; hormone antagonists; Humans; ion exchange; ionization; ions; Joining; Limit of Detection; Liquid chromatography; Mass spectrometry; Mass Spectrometry - methods; Medical sciences; narcotics; Pharmaceutical Preparations - chemistry; Pharmaceutical Preparations - urine; Pharmacology. Drug treatments; pretreatment; rapid methods; Reproducibility of Results; Retrospective analysis; Screening; solid phase extraction; sports; urine; High resolution mass spectrometry; Retrospective analysis; Doping control; Fast screening; Liquid chromatography; Bioanalysis; High throughput screening; Ultra performance liquid chromatography; Solid phase extraction; Biological fluid; Tandem mass spectrometry; Chemical analysis; Doping; Electrospray; Chemical enrichment; Sample preparation; Quantitative analysis; Drug; Urine; Validation; Healthy subject; Coupled method; Elimination; Reversed phase chromatography; Enzymatic digestion