A systematic review of the therapeutic potential of nicotinamide adenine dinucleotide precursors for cognitive diseases in preclinical rodent models

• Published in: BMC neuroscience Vol. 26; no. 1; pp. 17 - 15
• Main Authors: Qader, Musaab Abdulrazzaq, Hosseini, Leila, Abolhasanpour, Nasrin, Oghbaei, Farnaz, Maghsoumi-Norouzabad, Leila, Salehi-Pourmehr, Hanieh, Fattahi, Fatemeh, Sadeh, Reza Naghdi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.03.2025; BioMed Central; BMC
• Subjects: Advertising executives; Aging; Alzheimer's disease; Analysis; Animal cognition; Animal models; Animals; Apoptosis; Brain; Care and treatment; Citation management software; Cognition disorders; Cognitive ability; Cognitive Dysfunction - drug therapy; Cognitive Dysfunction - metabolism; Cognitive impairment; Dementia; Dementia disorders; Diabetes; Diabetes mellitus; Disease; Disease Models, Animal; Drinking water; Enzymes; Health aspects; Humans; Inflammation; Injuries; Kinases; Medical Subject Headings-MeSH; Memory; Mental disorders; Mitochondria; Mitochondria - drug effects; Mitochondrial dysfunction; NAD; NAD (Coenzyme); NAD - pharmacology; NAD - therapeutic use; Neurodegenerative diseases; Neurological research; Niacinamide; Nicotinamide; Online databases; Oxidative stress; Oxidative Stress - drug effects; Pathogenesis; Purines; Rats; Rodents; Schizophrenia; Synthesis; Systematic review; Traumatic brain injury; Vascular dementia; Iran; Oxidative stress; Inflammation; Nicotinamide; Mitochondrial dysfunction; Memory; Cognitive impairment

This systematic review sought to assess the impact of nicotinamide adenine dinucleotide (NAD ) precursors on cognitive impairments in several diseases in rat/mouse models. Accumulating evidence suggests that inflammation, apoptosis, oxidative stress responses, and mitochondrial dysfunction are poten...