Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir - Yin, Wanchao; Mao, Chunyou; Luan, Xiaodong; Shen, Dan-Dan; Shen, Qingya; Su, Haixia; Wang, Xiaoxi; Zhou, Fulai; Zhao, Wenfeng; Gao, Minqi; Chang, Shenghai; Xie, Yuan-Chao; et al. (Science (American Association for the Advancement of Science), 2020)
Keywords: Adenosine Monophosphate - analogs & derivatives; Adenosine Monophosphate - chemistry; Adenosine Monophosphate - metabolism; Adenosine Monophosphate - pharmacology; Alanine - analogs & derivatives; Alanine - chemistry; Alanine - metabolism; Alanine - pharmacology; Antiviral Agents - chemistry; Antiviral Agents - metabolism; Antiviral Agents - pharmacology; Antiviral drugs; Betacoronavirus - drug effects; Betacoronavirus - enzymology; Betacoronavirus - physiology; Biochem; Catalytic Domain; Coronaviridae; Coronavirus RNA-Dependent RNA Polymerase; Coronaviruses; COVID-19; Cryoelectron Microscopy; DNA-directed RNA polymerase; Double-stranded RNA; Drug development; Electron microscopy; Elongated structure; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - metabolism; Enzyme Inhibitors - pharmacology; Models, Molecular; Multiprotein Complexes - chemistry; Nucleotides; Pandemics; Protein Conformation; Replication; Respiratory diseases; RNA polymerase; RNA, Viral - chemistry; RNA, Viral - metabolism; RNA-Dependent RNA Polymerase - antagonists & inhibitors; RNA-Dependent RNA Polymerase - chemistry; RNA-Dependent RNA Polymerase - metabolism; RNA-directed RNA polymerase; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Transcription; Viral diseases; Viral Nonstructural Proteins - antagonists & inhibitors; Viral Nonstructural Proteins - chemistry; Viral Nonstructural Proteins - metabolism; Virus Replication; Viruses