A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2

• Published in: Science (American Association for the Advancement of Science) Vol. 368; no. 6496; pp. 1274 - 1278
• Main Authors: Wu, Yan, Wang, Feiran, Shen, Chenguang, Peng, Weiyu, Li, Delin, Zhao, Cheng, Li, Zhaohui, Li, Shihua, Bi, Yuhai, Yang, Yang, Gong, Yuhuan, Xiao, Haixia, Fan, Zheng, Tan, Shuguang, Wu, Guizhen, Tan, Wenjie, Lu, Xuancheng, Fan, Changfa, Wang, Qihui, Liu, Yingxia, Zhang, Chen, Qi, Jianxun, Gao, George Fu, Gao, Feng, Liu, Lei
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 12.06.2020; American Association for the Advancement of Science
• Subjects: ACE2; Angiotensin; Angiotensin-Converting Enzyme 2; Animals; Antibodies; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - isolation & purification; Antibodies, Monoclonal - therapeutic use; Antibodies, Neutralizing - immunology; Antibodies, Neutralizing - isolation & purification; Antibodies, Neutralizing - therapeutic use; Antibodies, Viral - immunology; Antibodies, Viral - isolation & purification; Antibodies, Viral - therapeutic use; Antiviral agents; Antiviral drugs; Binding sites; Biochem; Blocking; Cellular structure; Coronaviridae; Coronavirus Infections - therapy; Coronaviruses; COVID-19; Disease Models, Animal; Domains; Enzymes; Epitopes; Glycoproteins; Humans; Immune system; Immunodominant Epitopes - chemistry; Immunodominant Epitopes - immunology; Lung - immunology; Lung - virology; Mice; Microbio; Monoclonal antibodies; Neutralization; Neutralization Tests; Neutralizing; Pandemics; Peptidyl-dipeptidase A; Peptidyl-Dipeptidase A - immunology; Pneumonia, Viral - therapy; Protein Domains; Receptors; Receptors, Virus - immunology; Spike glycoprotein; Spike Glycoprotein, Coronavirus - immunology; Spike protein; Therapeutic applications; Viral diseases; Viral Load - immunology; Viruses

One of the responses of the immune system to invading viruses is the production of antibodies. Some of these are neutralizing, meaning that they prevent the virus from being infectious, and can thus be used to treat viral diseases. Wu et al. isolated four neutralizing antibodies from a convalescent...