A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2
One of the responses of the immune system to invading viruses is the production of antibodies. Some of these are neutralizing, meaning that they prevent the virus from being infectious, and can thus be used to treat viral diseases. Wu et al. isolated four neutralizing antibodies from a convalescent...
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| Published in | Science (American Association for the Advancement of Science) Vol. 368; no. 6496; pp. 1274 - 1278 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
The American Association for the Advancement of Science
12.06.2020
American Association for the Advancement of Science |
| Subjects | |
| Online Access | Get full text |
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| Abstract | One of the responses of the immune system to invading viruses is the production of antibodies. Some of these are neutralizing, meaning that they prevent the virus from being infectious, and can thus be used to treat viral diseases. Wu
et al.
isolated four neutralizing antibodies from a convalescent coronavirus disease 2019 (COVID-19) patient. Two of the antibodies, B38 and H4, blocked the receptor binding domain (RBD) of the viral spike protein from binding to the cellular receptor, angiotensin-converting enzyme 2 (ACE2). The structure of the RBD bound to B38 shows that the B38-binding site overlaps with the binding site for ACE2. Although H4 also blocks RBD binding to ACE2, it binds at a different site, and thus the two antibodies can bind simultaneously. This pair of antibodies could potentially be used together in clinical applications.
Science
, this issue p.
1274
A pair of neutralizing antibodies against COVID-19 bind to different epitopes to compete with cellular receptor binding.
Neutralizing antibodies could potentially be used as antivirals against the coronavirus disease 2019 (COVID-19) pandemic. Here, we report isolation of four human-origin monoclonal antibodies from a convalescent patient, all of which display neutralization abilities. The antibodies B38 and H4 block binding between the spike glycoprotein receptor binding domain (RBD) of the virus and the cellular receptor angiotensin-converting enzyme 2 (ACE2). A competition assay indicated different epitopes on the RBD for these two antibodies, making them a potentially promising virus-targeting monoclonal antibody pair for avoiding immune escape in future clinical applications. Moreover, a therapeutic study in a mouse model validated that these antibodies can reduce virus titers in infected lungs. The RBD-B38 complex structure revealed that most residues on the epitope overlap with the RBD-ACE2 binding interface, explaining the blocking effect and neutralizing capacity. Our results highlight the promise of antibody-based therapeutics and provide a structural basis for rational vaccine design. |
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| AbstractList | Neutralizing antibodies could potentially be used as antivirals against the coronavirus disease 2019 (COVID-19) pandemic. Here, we report isolation of four human-origin monoclonal antibodies from a convalescent patient, all of which display neutralization abilities. The antibodies B38 and H4 block binding between the spike glycoprotein receptor binding domain (RBD) of the virus and the cellular receptor angiotensin-converting enzyme 2 (ACE2). A competition assay indicated different epitopes on the RBD for these two antibodies, making them a potentially promising virus-targeting monoclonal antibody pair for avoiding immune escape in future clinical applications. Moreover, a therapeutic study in a mouse model validated that these antibodies can reduce virus titers in infected lungs. The RBD-B38 complex structure revealed that most residues on the epitope overlap with the RBD-ACE2 binding interface, explaining the blocking effect and neutralizing capacity. Our results highlight the promise of antibody-based therapeutics and provide a structural basis for rational vaccine design.Neutralizing antibodies could potentially be used as antivirals against the coronavirus disease 2019 (COVID-19) pandemic. Here, we report isolation of four human-origin monoclonal antibodies from a convalescent patient, all of which display neutralization abilities. The antibodies B38 and H4 block binding between the spike glycoprotein receptor binding domain (RBD) of the virus and the cellular receptor angiotensin-converting enzyme 2 (ACE2). A competition assay indicated different epitopes on the RBD for these two antibodies, making them a potentially promising virus-targeting monoclonal antibody pair for avoiding immune escape in future clinical applications. Moreover, a therapeutic study in a mouse model validated that these antibodies can reduce virus titers in infected lungs. The RBD-B38 complex structure revealed that most residues on the epitope overlap with the RBD-ACE2 binding interface, explaining the blocking effect and neutralizing capacity. Our results highlight the promise of antibody-based therapeutics and provide a structural basis for rational vaccine design. One of the responses of the immune system to invading viruses is the production of antibodies. Some of these are neutralizing, meaning that they prevent the virus from being infectious, and can thus be used to treat viral diseases. Wu et al. isolated four neutralizing antibodies from a convalescent coronavirus disease 2019 (COVID-19) patient. Two of the antibodies, B38 and H4, blocked the receptor binding domain (RBD) of the viral spike protein from binding to the cellular receptor, angiotensin-converting enzyme 2 (ACE2). The structure of the RBD bound to B38 shows that the B38-binding site overlaps with the binding site for ACE2. Although H4 also blocks RBD binding to ACE2, it binds at a different site, and thus the two antibodies can bind simultaneously. This pair of antibodies could potentially be used together in clinical applications. Science , this issue p. 1274 A pair of neutralizing antibodies against COVID-19 bind to different epitopes to compete with cellular receptor binding. Neutralizing antibodies could potentially be used as antivirals against the coronavirus disease 2019 (COVID-19) pandemic. Here, we report isolation of four human-origin monoclonal antibodies from a convalescent patient, all of which display neutralization abilities. The antibodies B38 and H4 block binding between the spike glycoprotein receptor binding domain (RBD) of the virus and the cellular receptor angiotensin-converting enzyme 2 (ACE2). A competition assay indicated different epitopes on the RBD for these two antibodies, making them a potentially promising virus-targeting monoclonal antibody pair for avoiding immune escape in future clinical applications. Moreover, a therapeutic study in a mouse model validated that these antibodies can reduce virus titers in infected lungs. The RBD-B38 complex structure revealed that most residues on the epitope overlap with the RBD-ACE2 binding interface, explaining the blocking effect and neutralizing capacity. Our results highlight the promise of antibody-based therapeutics and provide a structural basis for rational vaccine design. Neutralizing antibodies could potentially be used as antivirals against the coronavirus disease 2019 (COVID-19) pandemic. Here, we report isolation of four human-origin monoclonal antibodies from a convalescent patient, all of which display neutralization abilities. The antibodies B38 and H4 block binding between the spike glycoprotein receptor binding domain (RBD) of the virus and the cellular receptor angiotensin-converting enzyme 2 (ACE2). A competition assay indicated different epitopes on the RBD for these two antibodies, making them a potentially promising virus-targeting monoclonal antibody pair for avoiding immune escape in future clinical applications. Moreover, a therapeutic study in a mouse model validated that these antibodies can reduce virus titers in infected lungs. The RBD-B38 complex structure revealed that most residues on the epitope overlap with the RBD-ACE2 binding interface, explaining the blocking effect and neutralizing capacity. Our results highlight the promise of antibody-based therapeutics and provide a structural basis for rational vaccine design. An antibody defense against COVID-19One of the responses of the immune system to invading viruses is the production of antibodies. Some of these are neutralizing, meaning that they prevent the virus from being infectious, and can thus be used to treat viral diseases. Wu et al. isolated four neutralizing antibodies from a convalescent coronavirus disease 2019 (COVID-19) patient. Two of the antibodies, B38 and H4, blocked the receptor binding domain (RBD) of the viral spike protein from binding to the cellular receptor, angiotensin-converting enzyme 2 (ACE2). The structure of the RBD bound to B38 shows that the B38-binding site overlaps with the binding site for ACE2. Although H4 also blocks RBD binding to ACE2, it binds at a different site, and thus the two antibodies can bind simultaneously. This pair of antibodies could potentially be used together in clinical applications.Science, this issue p. 1274Neutralizing antibodies could potentially be used as antivirals against the coronavirus disease 2019 (COVID-19) pandemic. Here, we report isolation of four human-origin monoclonal antibodies from a convalescent patient, all of which display neutralization abilities. The antibodies B38 and H4 block binding between the spike glycoprotein receptor binding domain (RBD) of the virus and the cellular receptor angiotensin-converting enzyme 2 (ACE2). A competition assay indicated different epitopes on the RBD for these two antibodies, making them a potentially promising virus-targeting monoclonal antibody pair for avoiding immune escape in future clinical applications. Moreover, a therapeutic study in a mouse model validated that these antibodies can reduce virus titers in infected lungs. The RBD-B38 complex structure revealed that most residues on the epitope overlap with the RBD-ACE2 binding interface, explaining the blocking effect and neutralizing capacity. Our results highlight the promise of antibody-based therapeutics and provide a structural basis for rational vaccine design. One of the responses of the immune system to invading viruses is the production of antibodies. Some of these are neutralizing, meaning that they prevent the virus from being infectious, and can thus be used to treat viral diseases. Wu et al. isolated four neutralizing antibodies from a convalescent coronavirus disease 2019 (COVID-19) patient. Two of the antibodies, B38 and H4, blocked the receptor binding domain (RBD) of the viral spike protein from binding to the cellular receptor, angiotensin-converting enzyme 2 (ACE2). The structure of the RBD bound to B38 shows that the B38-binding site overlaps with the binding site for ACE2. Although H4 also blocks RBD binding to ACE2, it binds at a different site, and thus the two antibodies can bind simultaneously. This pair of antibodies could potentially be used together in clinical applications. Science , this issue p. 1274 A pair of neutralizing antibodies against COVID-19 bind to different epitopes to compete with cellular receptor binding. Neutralizing antibodies could potentially be used as antivirals against the coronavirus disease 2019 (COVID-19) pandemic. Here, we report isolation of four human-origin monoclonal antibodies from a convalescent patient, all of which display neutralization abilities. The antibodies B38 and H4 block binding between the spike glycoprotein receptor binding domain (RBD) of the virus and the cellular receptor angiotensin-converting enzyme 2 (ACE2). A competition assay indicated different epitopes on the RBD for these two antibodies, making them a potentially promising virus-targeting monoclonal antibody pair for avoiding immune escape in future clinical applications. Moreover, a therapeutic study in a mouse model validated that these antibodies can reduce virus titers in infected lungs. The RBD-B38 complex structure revealed that most residues on the epitope overlap with the RBD-ACE2 binding interface, explaining the blocking effect and neutralizing capacity. Our results highlight the promise of antibody-based therapeutics and provide a structural basis for rational vaccine design. |
| Author | Wang, Feiran Tan, Wenjie Lu, Xuancheng Peng, Weiyu Zhao, Cheng Bi, Yuhai Tan, Shuguang Gao, George Fu Li, Shihua Li, Delin Gao, Feng Fan, Zheng Fan, Changfa Liu, Yingxia Zhang, Chen Gong, Yuhuan Wang, Qihui Yang, Yang Xiao, Haixia Liu, Lei Li, Zhaohui Qi, Jianxun Wu, Guizhen Wu, Yan Shen, Chenguang |
| Author_xml | – sequence: 1 givenname: Yan orcidid: 0000-0003-2734-0673 surname: Wu fullname: Wu, Yan organization: Department of Pathogen Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China., Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China – sequence: 2 givenname: Feiran orcidid: 0000-0003-4568-9158 surname: Wang fullname: Wang, Feiran organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China., School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China – sequence: 3 givenname: Chenguang orcidid: 0000-0001-8607-3750 surname: Shen fullname: Shen, Chenguang organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China., Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People’s Hospital, Shenzhen, China – sequence: 4 givenname: Weiyu orcidid: 0000-0001-7069-9556 surname: Peng fullname: Peng, Weiyu organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China., College of Veterinary Medicine, China Agricultural University, Beijing, China – sequence: 5 givenname: Delin orcidid: 0000-0002-7967-1581 surname: Li fullname: Li, Delin organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China., Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People’s Hospital, Shenzhen, China., Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences (CAS), Tianjin, China – sequence: 6 givenname: Cheng orcidid: 0000-0001-9800-9107 surname: Zhao fullname: Zhao, Cheng organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China., Shanxi Academy of Advanced Research and Innovation, Taiyuan, China – sequence: 7 givenname: Zhaohui orcidid: 0000-0003-4286-7772 surname: Li fullname: Li, Zhaohui organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China., University of Chinese Academy of Sciences, Beijing, China – sequence: 8 givenname: Shihua orcidid: 0000-0003-3608-4106 surname: Li fullname: Li, Shihua organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China – sequence: 9 givenname: Yuhai orcidid: 0000-0002-5595-363X surname: Bi fullname: Bi, Yuhai organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China., Center for Influenza Research and Early Warning, Chinese Academy of Sciences (CASCIRE), Beijing, China – sequence: 10 givenname: Yang surname: Yang fullname: Yang, Yang organization: Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People’s Hospital, Shenzhen, China – sequence: 11 givenname: Yuhuan surname: Gong fullname: Gong, Yuhuan organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China., Center for Influenza Research and Early Warning, Chinese Academy of Sciences (CASCIRE), Beijing, China – sequence: 12 givenname: Haixia surname: Xiao fullname: Xiao, Haixia organization: Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences (CAS), Tianjin, China – sequence: 13 givenname: Zheng surname: Fan fullname: Fan, Zheng organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China – sequence: 14 givenname: Shuguang surname: Tan fullname: Tan, Shuguang organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China – sequence: 15 givenname: Guizhen orcidid: 0000-0003-2778-4290 surname: Wu fullname: Wu, Guizhen organization: NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China – sequence: 16 givenname: Wenjie orcidid: 0000-0002-5963-1136 surname: Tan fullname: Tan, Wenjie organization: NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China – sequence: 17 givenname: Xuancheng surname: Lu fullname: Lu, Xuancheng organization: Laboratory Animal Center, Chinese Center for Disease Control and Prevention, Beijing, China – sequence: 18 givenname: Changfa orcidid: 0000-0001-5556-2025 surname: Fan fullname: Fan, Changfa organization: Division of Animal Model Research, Institute for Laboratory Animal Resources, National Institutes for Food and Drug Control, Beijing, China – sequence: 19 givenname: Qihui surname: Wang fullname: Wang, Qihui organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China – sequence: 20 givenname: Yingxia surname: Liu fullname: Liu, Yingxia organization: Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People’s Hospital, Shenzhen, China – sequence: 21 givenname: Chen surname: Zhang fullname: Zhang, Chen organization: Department of Pathogen Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China – sequence: 22 givenname: Jianxun surname: Qi fullname: Qi, Jianxun organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China – sequence: 23 givenname: George Fu orcidid: 0000-0002-3869-615X surname: Gao fullname: Gao, George Fu organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China – sequence: 24 givenname: Feng orcidid: 0000-0002-0670-010X surname: Gao fullname: Gao, Feng organization: Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences (CAS), Tianjin, China – sequence: 25 givenname: Lei orcidid: 0000-0001-9612-6844 surname: Liu fullname: Liu, Lei organization: Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People’s Hospital, Shenzhen, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32404477$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1073/pnas.1705176114 10.1038/s41586-020-2012-7 10.1016/S0140-6736(20)30251-8 10.1016/S0140-6736(20)30154-9 10.1016/j.cell.2020.02.058 10.1126/science.abb2507 10.1002/pro.3330 10.1038/s41586-020-2008-3 10.1080/14728222.2017.1271415 10.1016/S0140-6736(20)30185-9 10.1016/j.cell.2020.02.052 10.1038/s41564-019-0411-z 10.3390/v11010060 10.1107/S0907444902016657 10.1107/S0907444904019158 10.46234/ccdcw2020.017 10.1038/nrmicro2090 10.1056/NEJMoa2001017 10.1016/j.tim.2015.06.003 10.1016/j.cell.2020.03.045 10.1016/S0076-6879(97)76066-X |
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| Snippet | One of the responses of the immune system to invading viruses is the production of antibodies. Some of these are neutralizing, meaning that they prevent the... Neutralizing antibodies could potentially be used as antivirals against the coronavirus disease 2019 (COVID-19) pandemic. Here, we report isolation of four... An antibody defense against COVID-19One of the responses of the immune system to invading viruses is the production of antibodies. Some of these are... |
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| SubjectTerms | ACE2 Angiotensin Angiotensin-Converting Enzyme 2 Animals Antibodies Antibodies, Monoclonal - immunology Antibodies, Monoclonal - isolation & purification Antibodies, Monoclonal - therapeutic use Antibodies, Neutralizing - immunology Antibodies, Neutralizing - isolation & purification Antibodies, Neutralizing - therapeutic use Antibodies, Viral - immunology Antibodies, Viral - isolation & purification Antibodies, Viral - therapeutic use Antiviral agents Antiviral drugs Binding sites Biochem Blocking Cellular structure Coronaviridae Coronavirus Infections - therapy Coronaviruses COVID-19 Disease Models, Animal Domains Enzymes Epitopes Glycoproteins Humans Immune system Immunodominant Epitopes - chemistry Immunodominant Epitopes - immunology Lung - immunology Lung - virology Mice Microbio Monoclonal antibodies Neutralization Neutralization Tests Neutralizing Pandemics Peptidyl-dipeptidase A Peptidyl-Dipeptidase A - immunology Pneumonia, Viral - therapy Protein Domains Receptors Receptors, Virus - immunology Spike glycoprotein Spike Glycoprotein, Coronavirus - immunology Spike protein Therapeutic applications Viral diseases Viral Load - immunology Viruses |
| Title | A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2 |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/32404477 https://www.proquest.com/docview/2412345379 https://www.proquest.com/docview/2403030277 https://pubmed.ncbi.nlm.nih.gov/PMC7223722 |
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