Anti-Anxiety Effects of Essential Oil Microemulsion in Chronic Unpredictable Mild Stress-Induced Rats: Preparation, Characterization, and Mechanisms

• Published in: Molecules (Basel, Switzerland) Vol. 30; no. 12; p. 2652
• Main Authors: Tang, Wenxia, Jiang, Pan, Hu, Ke, Mei, Duo, Jiao, Qinghao, Li, Yan, Deng, Yanping, Wang, Jun, Gao, Ran, Chen, Xin, Yu, Jie
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.06.2025; MDPI
• Subjects: Anesthesia; Animal behavior; Animals; Anti-Anxiety Agents - chemistry; Anti-Anxiety Agents - pharmacology; Antianxiety agents; Antidepressants; Anxiety; Anxiety - drug therapy; Anxiety disorders; Aromatherapy; aromatic plant essential oil; Behavior, Animal - drug effects; Citrus fruits; Disease Models, Animal; Emulsions - chemistry; Epidemiology; Essences and essential oils industry; GABA; Glutamate; herbal; Hippocampus - drug effects; Hippocampus - metabolism; Laboratory animals; Liver; Male; Medical research; Medicine, Experimental; Mental depression; Methylene blue; microemulsion; Microemulsions; Nervous system diseases; network pharmacology; Oils & fats; Oils, Volatile - chemistry; Oils, Volatile - pharmacology; Particle size; Physicochemical properties; Rats; Rats, Sprague-Dawley; sedative and hypnotic effects; Serotonin - metabolism; Stress; Stress, Psychological - drug therapy; Surveys; Traditional Chinese medicine; China; Sudan; Shanghai China; anxiety; aromatic plant essential oil; herbal; microemulsion; network pharmacology; sedative and hypnotic effects

Anxiety disorders, as common neurological diseases in clinical practice, often coexist with depression. Epidemiological surveys indicate that approximately 85% of patients with depression exhibit significant anxiety symptoms. This comorbid state not only exacerbates clinical symptoms but also leads...