Maternal diabetes adversely affects AMP-activated protein kinase activity and cellular metabolism in murine oocytes

• Published in: American journal of physiology: endocrinology and metabolism Vol. 293; no. 5; pp. E1198 - E1206
• Main Authors: Ratchford, Ann M, Chang, Aimee S, Chi, Maggie M.-Y, Sheridan, Rachael, Moley, Kelle H
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.11.2007
• Subjects: 3-Hydroxyacyl CoA Dehydrogenases - metabolism; Acetyl-CoA Carboxylase - metabolism; Adenosine Monophosphate - metabolism; Adenosine Triphosphate - metabolism; Alanine Transaminase - metabolism; Aminoimidazole Carboxamide - analogs & derivatives; Aminoimidazole Carboxamide - pharmacology; AMP-Activated Protein Kinases; Animals; Apoptosis; Cells; Diabetes; Diabetes Mellitus, Experimental - enzymology; Diabetes Mellitus, Experimental - metabolism; Endocrinology; Enzyme Activation - drug effects; Enzyme Activation - physiology; Female; Hypoglycemic Agents - pharmacology; Kinases; Metabolism; Metformin - pharmacology; Mice; Mice, Inbred C57BL; Multienzyme Complexes - metabolism; Oocytes - enzymology; Oocytes - metabolism; Pregnancy; Pregnancy in Diabetics - enzymology; Pregnancy in Diabetics - metabolism; Protein-Serine-Threonine Kinases - metabolism; Ribonucleotides - pharmacology; Rodents; Streptozocin

Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, Missouri Submitted 12 February 2007 ; accepted in final form 3 August 2007 Maternal diabetes is associated with an increased risk of miscarriages and congenital anomalies. Preovulatory oocytes in murine models al...