A novel model of urosepsis in mice developed by ureteral ligation and injection of Escherichia coli into the renal pelvis

• Published in: Heliyon Vol. 10; no. 3; p. e25522
• Main Authors: Hu, Haopu, Yan, Qiuxia, Tang, Xinwei, Lai, Shicong, Qin, Ziyu, Xu, Tao, Zhang, Hong, Hu, Hao
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.02.2024; Elsevier
• Subjects: adults; Animal model; animal models; blood; blood volume; body temperature; coagulation; Escherichia coli; glass; heart; interleukin-6; kidneys; leukocyte count; liver; lungs; males; Mice; mortality; Pathophysiology; pelvis; Urosepsis; Animal model; Urosepsis; Mice; Pathophysiology; Escherichia coli

Despite extensive investigations, urosepsis remains a life-threatening and high-mortality illness. The absence of widely acknowledged animal models for urosepsis prompted this investigation with the objective of formulating a replicable murine model. Eighty-four adult male C57BL/6J mice were arbitra...