Somatic mutations in tumor-infiltrating lymphocytes impact on antitumor immunity - Mukohara, Fumiaki; Iwata, Kazuma; Ishino, Takamasa; Inozume, Takashi; Nagasaki, Joji; Ueda, Youki; Suzawa, Ken; Ueno, Toshihide; Ikeda, Hideki; Kawase, Katsushige; Saeki, Yuka; Kawashima, Shusuke; et al. (Proceedings of the National Academy of Sciences, 2024)
Keywords: Animals; Anticancer properties; Antitumor activity; Biological Sciences; Biomarkers; Cancer; CD3 antigen; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Clonal deletion; Cloning; Female; Frameshift mutation; Gene deletion; Gene sequencing; Humans; Immune checkpoint inhibitors; Immune Checkpoint Inhibitors - pharmacology; Immune Checkpoint Inhibitors - therapeutic use; Immunity; Lymphocytes; Lymphocytes T; Lymphocytes, Tumor-Infiltrating - immunology; Melanoma; Melanoma - genetics; Melanoma - immunology; Mice; Mice, Knockout; Mutation; PD-1 protein; Phenotypes; Therapeutic targets; Tumor Necrosis Factor alpha-Induced Protein 3 - genetics; Tumor-infiltrating lymphocytes; Whole genome sequencing; tumor-infiltrating lymphocytes; somatic mutation; T cell; cancer immunology